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NCT Number: NCT07107776

Central Venous Oxygen Saturation Prognostic Impact in Post Arrest Patients

The study aim will be to assess the prognostic impact and value of central venous oxygen saturation on post arrest patients.

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Key information

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Central venous oxygen saturation (ScvO₂) is a very important measurement which can be easily taken in a critical care environment by both medical and nursing staff. It provides an understanding of the patient's oxygen delivery, oxygen consumption and cardiac output. It has a key role within early goal-directed therapy and has been shown to decrease mortality when taken and analysed appropriately. (Central venous oxygen saturation: analysis, clinical use and effects on mortality,2013) Venous oxygen saturation (SvO2) measures the blood's oxygen content returning to the right side of the heart after perfusing the entire body. When the oxygen supply is insufficient to meet the metabolic demands of the tissues, an abnormal SvO2 ensues and reflects an inadequacy in systemic oxygenation. SvO2 is, therefore, dependent on oxygen delivery and oxygen extraction. Venous oximetry is used in specific clinical settings of hemodynamic instability, such as in critical illnesses, perioperative periods of major surgeries, heart failure, sepsis andd post arrest patients. The venous blood in the pulmonary artery represents oxygen extraction in the whole body and is called mixed venous oxygen saturation (SmvO2). It was measured using a pulmonary artery catheter (PAC). A second, less invasive method of measuring SvO2 is via a central venous catheter (CVC) positioned in the superior vena cava and is called the central venous oxygen saturation (ScvO2).

Central venous oxygen saturation (ScvO(2)) is suggested to reflect the adequacy of oxygen delivery, and the main objective of the present study was to determine whether ScvO(2) is associated with outcome in haemodynamically stabilized post arrest patients predicting mortality and outcome based on central venous oxygen saturation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adults above 16 years old, critically ill patients
  • both genders
  • post arrest patients

Exclusion criteria

  • if patients does not experience cardiac arrest

Treatment and study plan

Primary outcomes

  1. central venous oxygen saturation impact on prognosis of post arrest patients

    Time frame: time of follow up expected from time of successful ROSC until full improvement or recurrent arrest and death From date of cardiac arrest until date of first documented improvement or date of death due to any cause whichever came first assessed up in 2 mo

    evaluating prognostic impact of oxygen saturation extracted from a central venous line blood sample on post arrest patients sample from (internal jagular vein) more or less than 50% oxygen saturation on prognosis of post arrest patients and recurrent arrests and overall improvement and time of expected and full recovery

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Central Venous Oxygen Saturation Impact on Prognosis of Post Arrest Patients

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Aug 6, 2025
Registry last updated
Aug 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.