Central Corneal Thickness in Glaucoma

The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma.

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Key information

Conditions

Exfoliation Syndrome Eye Diseases Iris Diseases Uveal Diseases

Age range

25 year–89 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Glaucoma Unit, 1st University Department of Ophthalmology

Thessaloniki, 546 36, Greece

About this study

To compare the central corneal thickness measurement in patients with exfoliation, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma. Prospective study in progress. Randomly selected patients undergo a comprehensive ophthalmic exam which includes 2 separate pachymetry measurements in 2 different examinations at the same time of the day (10:00 am) with 3 different pachymeters. The values obtained are correlated with a number of other glaucoma parameters. A thinner cornea may represent a specific attribute and an additional risk factor for patients with exfoliation. Evaluation of corneal thickness is an important exam in the management of patients with exfoliation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Exfoliation material on pupil
Intraocular pressure below 21 mm Hg without glaucomatous damage
Intraocular pressure above 21 mm Hg without glaucomatous damage
Raised intraocular pressure with glaucomatous damage

Exclusion criteria

Corneal disorders
History of trauma
Evidence of corneal abnormality that may influence IOP
Contact lens use
Corneal surgery

Treatment and study plan

Primary outcomes

central corneal thickness

Time frame: Morning measurement (10:00-11:00)

Secondary outcomes

Visual field, scanning laser polarimetry

Time frame: 10:00-11:00

Sponsors and collaborators

Lead sponsor

Aristotle University Of Thessaloniki

Other

Registry information

Official study title

Central Corneal Thickness in Patients With Exfoliation Syndrome, Exfoliative Glaucoma, Exfoliative Glaucoma, Primary Open-angle Glaucoma and Ocular Hypertension

Important dates

Study start: 2008
Primary completion: 2013
Study completion: 2013
First posted: Dec 2, 2009
Registry last updated: May 12, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed