Central and Peripheral Arterial Pressure Decoupling In Cardio-Pulmonary Bypass

Central and peripheral arterial pressure decoupling occurs in some clinical conditions like sepsis or cardiopulmonary bypass. This decoupling may leed to unsuitable decisions such as the use of catecholamines.

The aim of this study is to evaluate the pulse wave's speed as a marker of central and peripheral arterial pressure decoupling in a scheduled condition which is the cardiopulmonary bypass during cardiac surgery.

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Key information

Conditions

Cardiopulmonary Bypass Cardiac Surgery Extracorporeal Circulation

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospices Civils de Lyon

Bron, 69500, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Scheduled patient for coronary or valvular surgery with cardiopulmonary bypass
Cardiopulmonary bypass is at least 90 minutes
Written consent is needed

Exclusion criteria

Patient with heart rate disorder
Patient with aortic dissection
Dobutamine/milrinone/levosimendan treatment before surgery
Patient with heart rate due to a pacemaker

Treatment and study plan

Non-invasive blood pressure oscillometer (NIBP) implementation

Procedure

Implementation of two additional NIBP on humeral and femoral sites.

Primary outcomes

Measurement of femoral, radial and humeral pulses during a cardiopulmonary by-pass (CPBP).

Time frame: Day one (6 times)

Pulse wave's speed is calculated using 1) time between ECG R-wave and local detection of the pulse wave (femoral, humeral and radial) 2) a length from heart to these sites.

Wave detection at femoral and humeral sites will use oscillometry and wave detection at radial site will use an invasive catheter which is always set for this surgery.

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Collaborators

Université Joseph Fournier Grenoble 1

Registry information

Acronym: CAPD-CPB

Important dates

Study start: 2016
Primary completion: 2016
Study completion: 2016
First posted: Jan 12, 2016
Registry last updated: Sep 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed