Skip to main content
OpenTrials
Completed

NCT Number: NCT03642223

Central and Peripheral Adiposity and Iron Absorption

Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Adiposity Anemia Anemia, Hypochromic Anemia, Iron-Deficiency Body Weight Hematologic Diseases Hemic and Lymphatic Diseases Iron Deficiencies Iron Metabolism Disorders Iron-deficiency Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–55 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

American University of Beirut

Beirut, Lebanon

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • either normal-weight (BMI 18-25kg/m2) or overweight/obese (BMI 28-50kg/m2) with either central or peripheral fat deposits based on DEXA

Exclusion criteria

  • Iron Supplement or antibiotic intake within 2 weeks before study start
  • diagnosed chronic disease or gastrointestinal disorders
  • regular use of medication (except contraceptives)
  • pregnancy
  • lactation
  • smoking
  • blood donation or surgery within the last 4 months.

Treatment and study plan

Stable iron isotopes

Other

Participants have to consume a test meal containing stable iron isotopes in order to determine iron absorption

Primary outcomes

  1. Fractional and total iron absorption

    Time frame: 14days after the administration of the test meal

Secondary outcomes

  1. Serum Hepcidin

    Time frame: at baseline

  2. Serum ferritin

    Time frame: at baseline

    iron status

  3. Serum TfR

    Time frame: at baseline

    iron status

  4. Serum CRP

    Time frame: at baseline

    inflammation status

  5. Serum AGP

    Time frame: at baseline

    inflammation status

  6. Serum IL-6

    Time frame: at baseline

    inflammation status

Sponsors and collaborators

Lead sponsor

Swiss Federal Institute of Technology

Other

Collaborators

  • American University of Beirut Medical Center

Registry information

Official study title

Relation Btw Adiposity, Inflammation & Iron Absorption:Comparison Btw Central & Peripheral Adiposity

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Aug 22, 2018
Registry last updated
Mar 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.