Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients

Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver. Since transplant recipients are at risk for CMV or have evidence of infection with CMV, they are given an antiviral drug (usually ganciclovir or valganciclovir). Despite this, there are a chance that CMV infection may cause problems in the future. The purpose of this study is to assess how well patients'immune systems responds to the CMV virus, so that in the future it may be possible to predict which patients are at highest risk of CMV.

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Key information

Conditions

Transplant

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Health Network

Toronto, Ontario, M5G 2N2, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male or female patients who fulfill the following criteria are eligible for inclusion.

CMV D+/R- liver, kidney and heart recipient
CMV R+ liver,kidney and heart recipients who have received thymoglobulin induction therapy.
D+/R- and R+ lung transplant recipients.
Able to give written informed consent
Are willing and able to comply with the protocol
Age >=18 years

Exclusion criteria

Patient unwilling or unable to give informed consent

Treatment and study plan

Monitoring-blood samples drawn for CMV testing

Procedure

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Collaborators

The Physicians' Services Incorporated Foundation

Registry information

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2008
First posted: Feb 19, 2007
Registry last updated: Apr 16, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed