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NCT Number: NCT04088422

Cell Free DNA in Mature B-cell Lymphoma

The purpose of this study is to assess whether plasma cell free DNA is an accurate tool that can early and dynamically inform on treatment outcome and an accessible source of tumor DNA to track tumor clonal evolution.

Recruiting

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Key information

Conditions

Mature B-Cell Lymphoma

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ruijin hospital

Shanghai, Shanghai Municipality, 200025, China

Location status: Recruiting

Location contact

Pengpeng XU, MD, PhD

CONTACT

[email protected]

86-21-64370045 ext. 610707

Pengpeng XU, MD, PhD

SUB_INVESTIGATOR

Weili ZHAO, MD, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Documented diagnosis of mature B-cell tumor according to WHO 2008 criteria
  • 18 years or older

Exclusion criteria

  • Chemotherapy before
  • Other tumors

Treatment and study plan

Peripheral Blood Collection

Procedure

peripheral blood collection at treatment start, interm PET/CT, end of treatment PET/CT, one-year and two-year follow-up and or progression or relapse

Primary outcomes

  1. progression free survival

    Time frame: 2-year

Secondary outcomes

  1. overall survival

    Time frame: 2-year

  2. Complete Response rate

    Time frame: 6 weeks after treatment

Study contacts

Contact information is provided by the study sponsor or research team.

Weili Zhao, MD，PhD

CONTACT

[email protected]

64370045 ext. 610707

Sponsors and collaborators

Lead sponsor

Ruijin Hospital

Other

Registry information

Official study title

Prospective, Observational Study on Cell Free DNA Genotyping as a Tool to Inform Mature B-cell Lymphoma Management

Important dates

Study start
2022
Primary completion
2024
Study completion
2026
First posted
Sep 12, 2019
Registry last updated
Feb 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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