Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia

Defined by discharge from the hospital or antibiotic treatment for < 8 days without any of the following: requirement for antibiotic escalation, admission to an intensive care unit, mechanical or noninvasive ventilation, readmission within 30 days, or mortality within 30 days

Time in days from randomization until stability defined by temperature < 38, heart rate < 100, respiratory rate < 24, oxygen saturation > 90%, systolic blood pressure ≥ 90, and return to baseline mental status based on Glasgow Coma Score

The aggregate sum of days for which any amount of a specific antimicrobial agent was administered during the hospital encounter

Defined by a change in antibiotic therapy that may include switching to an antibiotic with a broader spectrum up activity, adding an additional antibiotic, or increasing the dose of prescribed antibiotics within 5 days of randomization

Admission to an intensive care unit or initiation of mechanical ventilation after randomization within the current hospitalization

Number of days within a 30-day follow-up period in which the patient is not hospitalized

Readmission for any reason within 30 days of hospital discharge

In-hospital death or discharge to hospice

Defined by encounter-associated ICD-10 diagnosis code during the current hospitalization

Defined by new or worsening abnormal value on liver function testing

Positive laboratory test for Clostridioides difficile within 30 days of randomization

Rank 1 (highest rank) = clinical cure as defined per the primary outcome Rank 2 = clinical cure with adverse event or abnormal liver function testing Rank 3 = intensive care unit admission or readmission Rank 4 = adverse event or liver injury and either intensive care unit admission or readmission Rank 5 = 30-day mortality