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Completed

NCT Number: NCT01974414

Cedar Honey in Oral Lichen Planus

The study aimed to evaluate the effect of cedar honey in treatment of erosive and atrophic oral lichen planus ( a common oral problem).

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Key information

Conditions

Erosive and Atrophic Oral Lichen Planus Atrophy Lichen Planus Lichen Planus, Oral Lichenoid Eruptions Mouth Diseases Neurologic Manifestations Pain Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Oral Medicine Department of Mashhad dental School,Oral and Maxillofacial diseases research center

Mashhad, Razavi Khorasan Province, Iran

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinically and histopathologically confirmed oral lichen planus without dysplasia in histopathologic evaluation
  • Severity of pain≥2 (VAS score)
  • Severity of lesions≥2 (tong prasom criteria)
  • absence of any treatment in the last month
  • absence of kidney or liver diseases( due to systemic administration of fluconazole to both groups)

Exclusion criteria

  • evidence of lichenoid reaction in clinical or histopathologic assessment
  • loss of follow up
  • pregnant patients
  • diabetic patients
  • any other mucosal disease
  • any severe systemic disease
  • patients who refuse doctor's advice
  • any unexpected adverse effect of honey

Treatment and study plan

orally administered cedar honey

Drug

Primary outcomes

  1. severity of lesions

    Time frame: 4 weeks

    severity of lesions due to thong prasom criteria

Secondary outcomes

  1. size of lesions

    Time frame: 4 weeks

    A sterile caulis was used to measure the maximum diameter of erosive and atrophic lesions and the maximum width perpendicular to the maximum diameter was recorded.

Other outcomes

  1. pain of lesions

    Time frame: 4 weeks

    Pain or burning sensation was assessed by using a visual analog scale (VAS). Patients marked the point from 0(no pain) to 10(extreme pain) representing their present pain perception

Sponsors and collaborators

Lead sponsor

Mashhad University of Medical Sciences

Other

Registry information

Official study title

Cedar Honey in Treatment of Oral Lichen Planus: a Randomized Clinical Trial

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Nov 1, 2013
Registry last updated
Nov 1, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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