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NCT Number: NCT04691037

CCTA Improves Clinical Management of Stable Chest Pain

The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

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Key information

Conditions

Coronary Computed Tomography Angiography Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Invasive Coronary Angiography Major Adverse Cardiovascular Events Myocardial Ischemia Optimal Medical Therapy Revascularization Stable Chest Pain Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Chaoyang Hospital, Beijing, Beijing Municipality, China

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • symptomatic patients with SCP suspected of obstructive CAD.
  • referred for CCTA for the assessment of SCP.
  • ≥18 years of age.
  • signed informed consent.

Exclusion criteria

  • acute coronary syndromes
  • previous CAD or coronary revascularization
  • nonsinus rhythm
  • cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons

Treatment and study plan

CCTA

Diagnostic Test

All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

Primary outcomes

  1. Major adverse cardiovascular events

    Time frame: 10 years

    Cardiac death and myocardial infarction

Secondary outcomes

  1. Invasive coronary angiography

    Time frame: 10 years

    Invasive coronary angiography occurred at follow-up after CCTA, attributed to CCTA results or unplanned.

  2. Medication prescription

    Time frame: 10 years

    Change for medication prescription of antiplatelet agents, anti-ischemic drugs, lipid-lowering agents, angiotensin-converting enzyme inhibition and so on, attributed to CCTA results or unplanned,

  3. Coronary revascularization

    Time frame: 10 years

    PTCA, PCI or CABG occurred at follow-up after CCTA, attributed to CCTA results or unplanned.

  4. Number of Participants with Death

    Time frame: 10 years

  5. Number of Participants with Stroke

    Time frame: 3 years

  6. Number of Participants with Cardiac death

    Time frame: 10 years

  7. Number of Participants with Myocardial infarction

    Time frame: 10 years

Study contacts

Contact information is provided by the study sponsor or research team.

Jia Zhou

CONTACT

[email protected]

+8615522485560

Sponsors and collaborators

Lead sponsor

Tianjin Chest Hospital

Other

Registry information

Official study title

Improving the Clinical Management of Stable Chest Pain Based on Imaging: a Registry of Computed Tomography Coronary Angiography

Acronym: CICM-SCP

Important dates

Study start
2016
Primary completion
2030
Study completion
2030
First posted
Dec 31, 2020
Registry last updated
Mar 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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