CCTA-based Coronary Plaque Characterization and High-sensitive Troponin T for the Prediction of Cardiovascular Outcomes

To determine the ability of semi-automated plaque assessment in cardiac computed tomography angiography (CCTA) and high sensitive troponin T (hsTnT) for the risk stratification of patients at intermediate risk for coronary artery disease (CAD).

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Noninvasive Plaque Characterization Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Heidelberg, Department of Cardiology, Heidelberg, Baden-Wurttemberg, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical indication for CCTA according to the current appropriate use criteria

Exclusion criteria

non-sinus rhythm
acute coronary syndromes
cardiomyopathies
moderate or severe valvular disease
elevated serum creatinine (>1.5 mg/dl)
history or ECG signs of previous myocardial infarction
severe iodine allergy.

Treatment and study plan

Primary outcomes

Cardiac death

Time frame: two years
Nonfatal myocardial infarction

Time frame: two years

Secondary outcomes

Myocardial revascularization including PCI and CABG

Time frame: two years

PCI - Percutaneous Coronary Intervention CABG - Coronary Artery Bypass Grafting

Sponsors and collaborators

Lead sponsor

University Hospital Heidelberg

Other

Collaborators

Heidelberg University
Semmelweis University Heart and Vascular Center

Registry information

Official study title

Comprehensive 'Bio-Imaging' Using Quantitative Coronary Plaque Composition Assessment and the High-sensitive Troponin T for the Prediction of Cardiac Outcomes.

Important dates

Study start: 2008
Primary completion: 2018
Study completion: 2018
First posted: Jan 8, 2014
Registry last updated: Sep 11, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed