Skip to main content
OpenTrials
Completed

NCT Number: NCT00350870

CBT With Disulfiram and Contingency Management

This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cocaine Abuse Chemically-Induced Disorders Cocaine-Related Disorders Mental Disorders Substance-Related Disorders

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

APT Foundation

New Haven, Connecticut, 06510, United States

About this study

This study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will be assigned to one of the following treatments:

  • placebo
  • disulfiram
  • placebo plus incentives for cocaine abstinence and medication compliance (prize CM)
  • disulfiram plus incentives for cocaine abstinence and medication compliance

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-50 year old
  • cocaine dependent
  • willing to sign consent
  • willing to accept randomization to intervention

Exclusion criteria

  • significant medical conditions
  • psychiatric disorder with current use of prescribed psychotropic medication
  • lifetime schizophrenia or bipolar disorder
  • suicidality or homicidality
  • unlikely to be able to complete 1 year follow up
  • unable to speak or read English at a third grade level

Treatment and study plan

Disulfiram

Drug

250mg per day of Disulfiram plus CBT

Other names: antabuse, antabus

Placebo

Drug

Placebo plus CBT

Placebo plus Contingency Management

Behavioral

Placebo plus Contingency Management for cocaine abstinence and medication compliance in addition to CBT

Disulfiram plus Contingency Management

Drug

250mg of Disulfiram plus Contingency Management for cocaine abstinence and medication compliance plus CBT.

Other names: antabuse, antabus

Primary outcomes

  1. Change in Cocaine Use by Self Report

    Time frame: 12 weeks

    Self-reports of substance use will be documented at each contact via the Substance Use Calendar. Similar to the Form-90 and the Time Line Follow-Back, which have been shown to be reliable and valid instruments for monitoring substance use and other outcomes in longitudinal studies202-204, the Substance Use Calendar allows a flexible, continuous evaluation of substance use on a daily basis.

  2. Change in Cocaine Use by Urine Toxicology Results

    Time frame: 12 weeks

    We will use the Roche onsite TESTCUP system for detection of cocaine, methamphetamine, THC, benzodiazepenes, and opioids.

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Maximizing the Efficacy of Cognitive Behavioral Therapy With Medication and Contingency Management

Important dates

Study start
2005
Primary completion
2010
Study completion
2010
First posted
Jul 11, 2006
Registry last updated
Dec 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.