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OpenTrials
Active, Not Recruiting

NCT Number: NCT03539575

CB1R in Synthetic Psychoactive Cannabinoids

The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Drug Dependence Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Connecticut Mental Health Center

New Haven, Connecticut, 06519, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion:

  • Able to provide written consent
  • Age 18-55
  • Current Synthetic Psychoactive Cannabinoids consumption

Exclusion:

  • MRI metal exclusions and claustrophobia
  • Education completed is less than 12 years

Treatment and study plan

[11-C]OMAR

Other

The radiotracer, [11-C]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Primary outcomes

  1. Positron Emission Tomography (PET Imaging)

    Time frame: Change in CB1R availability from baseline throughout one test day

    CB1R availability using [11-C]OMAR PET imaging Change in CB1R availability (e.g. volume distribution).

Secondary outcomes

  1. CogState Battery

    Time frame: Change in CB1R availability from baseline throughout one test day

    • Changes in Cognition during withdrawal using a computerized battery Changes in cognitive functions such as attention, memory, motor functioning, and processing speed.

  2. Electroencephalogram

    Time frame: Change in CB1R availability from baseline throughout one test day

    • Changes in brain rhythms measured by Electroencephalography Changes in electroencephalographic (EEG) brain rhythms related to information processing.

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)
  • National Institutes of Health (NIH)

Registry information

Official study title

CB1R Availability in Synthetic Psychoactive Cannabinoid Users

Acronym: CB1R in Spice

Important dates

Study start
2018
Primary completion
2026
Study completion
2026
First posted
May 29, 2018
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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