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NCT Number: NCT06467877

Causes, Characteristics and Treatment of Hypercalcemia in the Emergency Room of a German Hospital

Patients with hypercalcemia were identified in the patient population of a German emergency department during a 11 year time period and studied regarding reproducibility of elevated calcium values, causes of hypercalcemia, symptoms. acute renal injury, mortality and treatment response.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Hypercalcemia Calcium Metabolism Disorders Disease Attributes Emergencies Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Water-Electrolyte Imbalance

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department II of Internal Medicine,University of Cologne

Cologne, 50937, Germany

About this study

Patients, who presented to the emergency department of a tertiary German hospital with a total calcium of ≥2.65 mmol/l between January 2010 and March 2021, was retrospectively studied. From the electronic patient records we analyzed if the elevated calcium values were reproducible in follow-up measurements, identified the cause of hypercalcemia, listed the symptoms, investigated a correlation between calcium and creatinine values to study acute renal injury directly due to hypercalcemia, calculated the mortality rate stratified by the calcium value on presentation and studied the treatment response regarding lowering calcium values by different treatments.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 18 years
  • Total calcium ≥ 2.65 mmol/l
  • Female and male

Exclusion criteria

  • Age < 18 years
  • Total calcium < 2.65 mmol/

Treatment and study plan

Primary outcomes

  1. Development of total calcium values

    Time frame: 5 days after enrollment

    Overview of total calcium values within 5 days

Secondary outcomes

  1. Reproducibility of elevated calcium values

    Time frame: 5 days after enrollment

    Determination of cause of hypercalcemia, of symptoms, of treatment response. In dependence of hospital stay, kann be determined later than 5 days after enrollment

  2. Correlation creatinine calcium

    Time frame: 5 days after enrollment

    Determination of correlation between calcium and creatinine.

  3. Mortality

    Time frame: 5 days after enrollment

    occurence of death within of 5 days after enrollment

Sponsors and collaborators

Lead sponsor

University of Cologne

Other

Registry information

Official study title

Retrospective Analysis of Causes, Clinical Presentation and Treatment in Patients With Hypercalcaemia in the Emergency Department of a Tertiary German Hospital

Important dates

Study start
2010
Primary completion
2021
Study completion
2025
First posted
Jun 21, 2024
Registry last updated
Dec 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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