Skip to main content
OpenTrials
Completed

NCT Number: NCT00293696

Casodex/Zoladex Biomarkers in Localised Prostate Cancer

To evaluate anti-androgen (bicalutamide) induced biological and molecular changes in prostate comparison to chemical castration induced (goserelin) ones

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Prostate Cancer Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

18 year–70 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Primary location

TUCH

Tampere, 33521, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Histologically confirmed localised prostate biopsy specimen that contains sufficient tumour for evaluation of cell proliferation and apoptosis markers
  • Patients who are scheduled for radical prostatectomy with curative intents

Treatment and study plan

bicalutamide (Casodex), goserelin (Zoladex)

Drug

Primary outcomes

  1. Proliferation by Ki67,

  2. apoptosis marker (TUNEL assay),

  3. Gleason score

Secondary outcomes

  1. expression of known androgen-regulated genes,

  2. biomarkers of apoptotic pathway,

  3. (novel) genomic transcripts

Sponsors and collaborators

Lead sponsor

Tampere University

Other

Registry information

Official study title

A Randomised Pilot Study to Evaluate the Effect(s) of Casodex 150 mg and Zoladex 3.6 mg on Pathological and Genomic Tumour Markers in Subjects Undergoing Radical Prostatectomy for Localised Prostate Carcinoma

Important dates

Study start
2004
Study completion
2006
First posted
Feb 17, 2006
Registry last updated
May 8, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.