Case Control Study to Identify Modifiable Risk Factors for Colorectal and Breast Cancer in Nigeria

This project is a case-control study which seeks to identify modifiable risk factors for breast and colorectal cancer in Nigeria. Both cases and controls will be required to complete a risk factor questionnaire which contains information about their diet, physical activity, past medical history and life style factors. They will also be required to provide information on their body composition through the use of a bioimpedance machine which measures the body mass index, fat and total body water percentage.

Based on the existing ARGO platform where a current colorectal cancer study is going on, approximately 400 patients with a prior diagnosis or a new diagnosis will be recruited into this study. Comparatively, we will select our 400 controls from two groups of participants who are free of cancer and gastrointestinal diseases.

Recruiting

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Key information

Conditions

Colorectal Cancer Breast Cancer Breast Diseases Breast Neoplasms Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases Skin Diseases Skin and Connective Tissue Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Obafemi Awolowo University Teaching Hospitals

Ile-Ife, Osun State, 220005, Nigeria

Location status: Recruiting

Location contact

Olusegun I Alatise, FWACS

CONTACT

[email protected]

2348033859387

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Case Group - Patients must have histologically confirmed diagnosis of colorectal or breast cancer.

Control Group - Patients must not have a diagnosis of cancer.

Treatment and study plan

Questionnaire

Behavioral

Questionnaire containing questions regarding diet, physical activity, past medical history and life style practices.

Bioimpedance/Body Composition Unit

Device

Patients will provide information on body composition through the use of a bioimpedance machine which measures the body mass index, fat and total body water.

Primary outcomes

Development and Validation of Questionnaire For Assessing Modifiable Risk Factors for Cancer in Sub-Saharan Africa

Time frame: 2 years
Determination of Novel Modifiable Cancer Risk Factors in a Nigerian Population

Time frame: 2 years

We will determine the presence of established, plausible, and novel cancer risk factors in cases (n=400) and controls (n=400) in Nigeria

Sponsors and collaborators

Lead sponsor

Obafemi Awolowo University Teaching Hospital

Other

Collaborators

Federal Medical Centre, Owo
Lagos State University
Memorial Sloan Kettering Cancer Center
National Hospital, Abuja
University of Ilorin Teaching Hospital
University of Maiduguri Teaching Hospital

Registry information

Important dates

Study start: 2021
Primary completion: 2026
Study completion: 2026
First posted: Sep 16, 2021
Registry last updated: Mar 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting