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OpenTrials
Completed

NCT Number: NCT00810550

Carotid Ultrasound in the Evaluation of Heart Failure

Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle). The standard test to find coronary artery disease is coronary angiography. This test is highly accurate but is invasive and carries a small risk of complications. This study investigates ultrasound of the carotid (neck) arteries as a screening test for severe coronary artery disease as a cause of left ventricular systolic dysfunction. It is hypothesized that carotid ultrasound will have excellent negative predictive value for severe CAD.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiomyopathies Cardiomyopathy Cardiovascular Diseases Coronary Disease Heart Diseases Heart Failure Myocardial Ischemia Vascular Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle). The standard test to find coronary artery disease is coronary angiography. This test is highly accurate but is invasive and carries a small risk of complications. This study investigates ultrasound of the carotid (neck) arteries as a screening test for severe coronary artery disease as a cause of left ventricular systolic dysfunction. It is hypothesized that carotid ultrasound will have excellent negative predictive value for severe CAD.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • LVEF 40% or less

Exclusion criteria

  • Prior diagnosis of coronary or carotid obstructive atherosclerosis

Treatment and study plan

Carotid Ultrasound

Other

Measurement of intima-media thickness

Primary outcomes

  1. Diagnostic accuracy for severe CAD

    Time frame: 1 Day

Secondary outcomes

  1. Diagnostic accuracy for significant CAD

    Time frame: 1 Day

Sponsors and collaborators

Lead sponsor

NYU Langone Health

Other

Registry information

Acronym: CUE-HF

Important dates

Study start
2005
Primary completion
2008
Study completion
2008
First posted
Dec 18, 2008
Registry last updated
Apr 6, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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