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NCT Number: NCT05821894

Carotid Plaque Imaging Project (CPIP)

The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (VP), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. Possible approaches for early detection of VP include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. In the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for VP. The investigators also study plaque structure with imaging methods and try to develop new ways to detect VP using circulating or imaging markers.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Atherosclerotic Plaque Cardiovascular Diseases Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Plaque, Atherosclerotic Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Skåne University Hospital (SUS)

Malmö, Skåne County, 214 28, Sweden

Location status: Recruiting

Location contact

Isabel Goncalves, MD, PhD

CONTACT

[email protected]

+46 40 331000

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients older than 18 years old, male or female that are eligible for carotid endarterectomy due to atherosclerosis and that can provide informed consent.

Exclusion criteria

  • Patients younger than 18 years old that cannot provide informed consent; pregnant.

Treatment and study plan

observational study

Other

Primary outcomes

  1. Number of participants suffering post-operative cardiovascular events (by 2025)

    Time frame: Follow up assessment year 2025 (recording of events occurring since 2023)

    Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)

  2. Number of participants suffering post-operative cardiovascular events (by 2027)

    Time frame: Follow up assessment year 2027 (recording of events occurring since 2025)

    Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)

  3. Number of participants suffering post-operative cardiovascular events (by 2029)

    Time frame: Follow up assessment year 2029 (recording of events occurring since 2027)

    Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)

Study contacts

Contact information is provided by the study sponsor or research team.

Isabel Goncalves, MD, PhD

CONTACT

[email protected]

+46 40 331000

Sponsors and collaborators

Lead sponsor

Lund University

Other

Collaborators

  • Region Skane
  • Skåne University Hospital funds (incl. the Medical Training and Research Agreement/ALF)
  • Swedish Foundation for Strategic Research
  • Swedish Heart Lung Foundation
  • The Swedish Research Council

Registry information

Official study title

Carotid Plaque Imaging Project (Identification of Vulnerable Atherosclerotic Plaques With Imaging and Biological Markers)

Acronym: CPIP

Important dates

Study start
2005
Primary completion
2029
Study completion
2029
First posted
Apr 20, 2023
Registry last updated
Oct 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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