Carotid Doppler Screening for Subclinical Atherosclerosis in Diabetic CKD Patients.

This study is being done at Assiut University to look for early signs of hardening of the arteries (atherosclerosis) in people who have both diabetes and chronic kidney disease (CKD). Many patients with these conditions are at higher risk of heart disease and stroke, but the disease can develop quietly without symptoms.

We will use a safe, non-invasive test called carotid Doppler ultrasound, which uses sound waves to check the neck arteries (carotid arteries) for early changes. The goal is to see how often these early changes occur in patients with diabetes and CKD, and whether the findings relate to their kidney function, blood sugar control, and other health factors.

This research may help doctors detect vascular problems earlier and guide better prevention strategies for patients at risk.

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Key information

Conditions

Diabetes Mellitus, Type 2 Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Chronic Disease Chronic Kidney Disease Diabetes Mellitus Disease Attributes Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glucose Metabolism Disorders Kidney Diseases Male Urogenital Diseases Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Age≥18years.
Diagnosis of type 2 diabetes mellitus (per treating physician or ADA criteria).
CKDstage3:eGFR30-59mL/min/1.73 m² on at least two measurements ≥3 months apart OR established diagnosis in medical record.
Clinically stable (no AKI, no hospitalization for cardiovascular event in past 3 months).
Ableandwilling to provide informed consent.

Treatment and study plan

Primary outcomes

Prevalence of subclinical carotid atherosclerosis (defined as increased carotid intima-media thickness and/or carotid plaque detected by carotid Doppler ultrasound).

Time frame: At baseline (single assessment at enrollment).

Carotid Doppler ultrasound will be performed once at study entry to measure carotid intima-media thickness and detect the presence of carotid plaque. The percentage of patients with subclinical carotid atherosclerosis will be estimated among adults with type 2 diabetes mellitus and stage 3 chronic kidney disease.

Sponsors and collaborators

Lead sponsor

Abdallah Ali Mohammed

Other

Registry information

Official study title

Screening for Subclinical Atherosclerosis in Diabetic CKD Using Carotid Doppler

Acronym: DiCKD-CAROTID

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Dec 5, 2025
Registry last updated: Dec 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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