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NCT Number: NCT05938049

Carotid Doppler and IVC Measurements for Volume Guided Management in Acute Kidney Injury Patients

1. Evaluate Inferior Vena Cava Indices (Diameters , IVC-CI)&carotid doppler measurements (corrected Carotid Flow Time ,Carotid Blood Flow ,Carotid Artery Peak Velocity Variations) as Non-Invasive Technique for volume guided management in AKI Patient. 2. Estimate correlation between IVC (Diameters , IVC-CI) & carotid doppler measurements (corrected Carotid Flow Time ,Carotid Blood Flow ,Carotid Artery Peak Velocity Variations) as Non-Invasive Technique for volume guided management in AKI Patient.

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Key information

About this study

Acute kidney injury affects increasing numbers of patients worldwide, it was estimated approximately 15% of all subjects treated in hospitals develop Acute kidney injury,even a small increase in serum creatinine may be associated with increased risk of mortality , Oliguric AKI it imposes a great challenge for fluid management.

Recently, ultrasonography for estimating volume status has been widely recommended because of its non-invasive nature, ease of acquisition, and reproducibility of measurements.Among these ultrasound modalities, ultrasonographic assessment of the inferior vena cava & Carotid doppler measurements .

In spontaneously breathing patients, the inferior vena cava (IVC) diameter and the IVC Collapsibility Index (IVC-CI) have been shown to correlate with the volume status and central venous pressure (CVP) . also has been shown to indicate fluid status in children , ventilated patients and healthy volunteers .

corrected Carotid Flow Time (CFT) unaffected by respiration predicting fluid responsiveness that has shown promising results.Studies to date have shown that corrected CFT increases in response to fluid administration or consumption , and decreases in response to volume removal in dialysis and blood donation .

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with Acute Kidney Injury
  • age must be more than 18 years

Exclusion criteria

  • Morbid obesity (BMI >35)
  • End Stage Renal Disease (ESRD) on dialysis
  • Sever ventricular dysfunction, valvular heart disease
  • Carotid stenosis >50%
  • chronic obstructive pulmonary disease.
  • Pregnancy & tense ascites

Treatment and study plan

IVC ultrasound & Carotid doppler

Device

bed side ultrasonographic assessement of inferior vena cava maximum and minimum diameters 2 to 5 cm caudal to its junction with the right atrium over a single respiratory cycle , inferior vena cava collapsibility index (IVC-CI) will calculated as (IVC max - IVC min)/IVC max).

carotid doppler assessment (2-3 cm proximal to the carotid bulb in the longitudinal plane) of corrected carotid flow time(systole time/√cycle time) ,carotid artery peak velocity variation calculated as ([PV max- PV min]/PV mean) × 100, where PV mean = (PV max + PV min)/2. during three consecutive respiratory cycles. as part of their routine care and assessment

Primary outcomes

  1. percentage of participants with improved serum creatinine level in µmol/L in groups A and B.

    Time frame: at 48 hours

    percentage of participants with improved serum creatinine level in µmol/L in groups A and B.

  2. percentage of participants with improved urine out put in ml/kg/h in groups A and B.

    Time frame: at 48 hours

    percentage of participants with improved urine out put in ml/kg/h in groups A and B.

Secondary outcomes

  1. percentage of participants with improved mean arterial blood pressure in mmHg in groups A and B.

    Time frame: at 48 hours

    percentage of participants with improved mean arterial blood pressure in mmHg in groups A and B.

Study contacts

Contact information is provided by the study sponsor or research team.

Ayman Mohamed, dectorate

CONTACT

[email protected]

+201032413647

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Carotid Doppler and Inferior Vena Cava Measuerments for Volume Guided Management in Acute Kidney Injury Patients

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 10, 2023
Registry last updated
Aug 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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