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Recruiting

NCT Number: NCT07221643

Carotenoids in the Skin and Immune Aging

This study aims to examine the connection between the level of carotenoids in the skin and a number of immune related health parameters.

Recruiting

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Key information

Conditions

No Condition Skin Carotenoids and Immune-aging

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford Health - General Dermatology Clinic

Redwood City, California, 94063, United States

Location status: Recruiting

Location contact

Anne Lynn S. Chang, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Willing and able to provide written informed consent
  • Age 18-30 years OR 65 years and older
  • Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed)
  • Fiitzpatrick I-VI (all skin types)

Exclusion criteria

  • Pregnant or breastfeeding
  • uncontrolled medical conditions
  • Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis
  • Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others)
  • Unable to follow study protocol

Treatment and study plan

Primary outcomes

  1. Skin carotenoid levels and skin aging features

    Time frame: one day

    We will assess the skin carotenoid levels' correlation with skin aging features, such as wrinkles, fine lines, and age spots.

Secondary outcomes

  1. Skin carotenoid levels and biomarkers of aging

    Time frame: one day

    We will assess the skin carotenoid levels' correlation with biomarkers associated with aging, such as C-reactive protein, telomere length, telomerase activity etc.

  2. Skin carotenoid levels and self-reported perception of health

    Time frame: 2 weeks

    We will assess the skin carotenoid levels' correlation with self reported scores on general health and health beliefs, incidence of respiratory, gut and skin allergy symptoms, and sleep quality.

Study contacts

Contact information is provided by the study sponsor or research team.

Po-Han Ho, MD

CONTACT

[email protected]

Xiaochen Zhong, BA

CONTACT

[email protected]

408-816-0111

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Carotenoids in the Skin and Immune Aging: a Pilot Observational Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Oct 28, 2025
Registry last updated
Dec 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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