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NCT Number: NCT06838182

Caries-associated Saliva Biomarkers Among Different Races

discover possible differences and develop effective preventative interventions by examining the relationship between salivary biomarkers and caries prevalence across different racial groups and Detect risk factors involved in caries incidence .

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Key information

Age range

18 year–25 year

Sex eligibility

All sexes

Study type

Observational

About this study

Dental caries is a multifactorial condition that is influenced by both external and internal variables. Tooth decay progression is directly influenced by host factors, including the individual's immune competence, saliva flow rate and buffering capacity, tooth form, and bacterial makeup .

While salivary biomarkers are essential for predicting the risk of dental caries, little is known about how they relate to caries in a variety of populations. By examining the relationship between salivary biomarkers and caries prevalence across several racial groups, this study seeks to close this gap and enhance culturally appropriate preventive approaches . There have been contentious discussions over the causes of differences in oral health during the past forty years. The term "structural inequities" refers to the social, environmental, economic, and cultural determinants of health, which are frequently impacted by racial or ethnic background, gender, work status, immigrant status, and geographic location. Racialized populations have demonstrated greater rates of untreated dental decay (caries), severe periodontal disease, and total or partial edentulism . Typically, "race" refers to an individual's physical characteristics, such as skin tone or hair type, which may indicate their ancestry. White, African American, or Asian descent are some examples of classifications that are frequently used to characterize race .

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age : 19-25
  • We will have 2 groups according to ICDAS classification : Not severe (ICDAS score ≤3) / Severe (ICDAS score ≥3)

Exclusion criteria

  • : Those who reported daily use of alcohol or tobacco .
  • Those who used antibiotics or other systemic drugs within the previous three months .
  • Those who regularly used antiseptics

Treatment and study plan

Salivary biomarkers tests

Diagnostic Test

saliva samples are collected from participants

Primary outcomes

  1. the patient has caries or not according to ELISA and colorimetric assay

    Time frame: 3 months

    Change in concentration of salivary PRP( proline rich proteins) levels (ng\\ml )

Study contacts

Contact information is provided by the study sponsor or research team.

Fatma ahmed al safy, Master degree

CONTACT

[email protected]

00201145084182

shereen hafez ibrahim, phd

CONTACT

[email protected]

01099296591

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Caries-associated Saliva Biomarkers in Caries Experienced and Caries Free Population Among Different Races: Diagnostic Accuracy Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 20, 2025
Registry last updated
Feb 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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