Cardiovascular Risk Markers in Spinal Cord Injured Subjects of the Wheelchair Dancer Study

The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood markers, echocardiography of the heart and peripheral vessels, as well as blood pressure and arterial stiffness, in subjects performing either wheelchair dancing, wheelchair marathon or no sports. Further, it will be investigated, whether there is an association between neuroplasticity and cardiovascular health, as measured by electroencephalography (EEG), transcranial magnetic stimulation (TMS) and blood levels of the brain-derived neurotrophic factor (BDNF).

We hypothesize that the cardiovascular, physical and psychological benefits of wheelchair dancing and/or wheelchair marathon parallel improved neuroplasticity in SCI-patients

Completed

Looking for future studies?

Notify Me

Key information

Conditions

SCI - Spinal Cord Injury Cardiovascular Risk Factor Central Nervous System Diseases Nervous System Diseases Spinal Cord Diseases Spinal Cord Injuries Trauma, Nervous System Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University Salzburg, Salzburg, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

wheelchair users independent of the cause of the walking impairment, preferably with spinal cord injury.

Exclusion criteria

metallic implanters, additional neurologic pathologies, pregnancy

Treatment and study plan

Primary outcomes

comparison of cardiovascular risk factors between different study groups

Time frame: October 2017- June 2018

measurement for arterial stiffness parameters, via pulse wave analysis. Comparison between healthy individuals and patients using wheelchairs (three different groups).
Evaluation of echocardiography results between different study groups

Time frame: October 2017- June 2018

Evaluation of echocardiography comparing healthy individuals and patients using wheelchairs (three different groups).

Sponsors and collaborators

Lead sponsor

Paracelsus Medical University

Other

Registry information

Official study title

Associations Between the Cardiovascular Risk Markers and Neuroplasticity in Sedentary or Physically Active Spinal Cord Injured Subjects of the Wheelchair Dancer Study

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2021
First posted: Nov 24, 2017
Registry last updated: Jan 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed