Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes Respiration

The purpose of the trial is to investigate the cardiovascular response to peripheral chemoreceptor stimulation in Congestive Heart Failure with Cheyne- Stokes Respiration

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Key information

Conditions

Heart Failure, Congestive Cardiovascular Diseases Cheyne-Stokes Respiration Heart Diseases Heart Failure Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Moderate to severe heart failure (NYHA Class II or above) on optimal medical therapy
LVEF less than or equal to 45%
Stable condition as defined as no hospital admission or changes to medical therapy within two weeks prior to enrolment

Exclusion criteria

Patients taking known respiratory stimulants or depressants
Clinically significant asthma requiring therapy
Significant parenchymal lung disease
Primary pulmonary hypertension
Myocardial infarction within three months prior to enrolment
Patients with cardiac resynchronisation devices and permanent pacemakers
Anaemic (haemoglobin < 12g/dL)

Treatment and study plan

Experimental lung function test

Procedure

Administration of several CO2 gas mixtures

Primary outcomes

Cardiovascular parameters such as continuous blood pressure and heart rate.

Time frame: During administration of the intervention

Sponsors and collaborators

Lead sponsor

ResMed

Industry

Registry information

Official study title

Cardiovascular Response to Peripheral Chemoreceptor Stimulation in Congestive Heart Failure With Cheyne- Stokes Respiration

Important dates

Study start: 2007
Primary completion: 2010
Study completion: 2010
First posted: Jul 2, 2007
Registry last updated: Jul 27, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed