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Completed

NCT Number: NCT06529068

Cardiovascular Response to Isometric BFR Exercise

The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is:

The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff).

Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.

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Key information

Conditions

Blood Pressure

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cardiovascular Aging Research Laboratory

Austin, Texas, 78712-1415, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.

Exclusion criteria

  • Abnormal clotting times
  • Acid-base imbalance/acidosis
  • Arterial calcification
  • Atherosclerotic vessels
  • Cardiopulmonary conditions
  • Diabetes
  • Dialysis/central venous access
  • General/local infection
  • High intracranial pressure
  • Hip, pelvis, or femur fracture
  • History of venous thromboembolism
  • Hypertension
  • Immobility for greater than 48 hours in the past month
  • Immobilizing cast
  • Implanted medical device
  • Lymphectomies
  • Obesity
  • Open fracture
  • Open or unhealed soft tissue injuries
  • Paralysis
  • Peripheral vascular disease
  • Pregnancy/postpartum
  • Prior revascularization
  • Renal compromise
  • Severe crush injuries
  • Sickle cell trait/anemia
  • Skin grafts
  • Stroke
  • Temporary nerve damage
  • Thrombophilia
  • Tumor/cancer
  • Varicose veins
  • Vascular grafting

Treatment and study plan

Isometric handgrip exercise

Behavioral

The participants will perform isometric handgrip exercises without blood flow restriction.

Isometric handgrip exercise with a narrow-elastic band

Behavioral

The participants will perform isometric handgrip exercises with blood flow restriction using a narrow-elastic band.

Isometric handgrip exercise with a wide-rigid cuff

Behavioral

The participants will perform isometric handgrip exercises with blood flow restriction using a wide-rigid cuff.

Primary outcomes

  1. Systolic blood pressure and diastolic blood pressure

    Time frame: 20 minutes

    Beat-by-beat (both systolic and diastolic blood pressure) blood pressure before, during, and after exercise

  2. Brachial artery diameter evaluated by an ultrasound machine

    Time frame: Before and 20 minutes after exercise

    Brachial artery diameter will be measured by an ultrasound machine to calculate flow-mediated dilation (FMD)

  3. Heart rate

    Time frame: 20 minutes

    Monitor heart rate continuously before, during, and after exercise

Sponsors and collaborators

Lead sponsor

Hirofumi Tanaka

Other

Registry information

Official study title

Blood Pressure Responses to Isometric Blood Flow Restriction Exercise

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 31, 2024
Registry last updated
Jun 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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