Cardiovascular Patients With no Standard Modifiable Risk Factors

A growing number of patients develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of standard modifiable risk factors (SMuRF-less). There is scarcity of studies that address this issue in the Middle Eastern population.

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Key information

Conditions

Cardiovascular Risk Factors Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Istishari Hospital, Amman, Jordan

About this study

Atherosclerotic coronary artery disease (ASCAD) claims millions of lives annually on a global level and is the leading cause of death in the Middle East. There are four standard modifiable cardiovascular risk factors (SMuRFs): hypertension, type 2 diabetes mellitus, dyslipidemia, and smoking. These are very common in the Middle East and are crucial to be screened for and addressed in an affective manner.

However, an increasing proportion of patients with ASCVD have none of these individual factors (SMuRF-less). Globally, this proportion comprises 11.6% of individuals with stable coronary disease and heart attack. No prior study has addressed the issue of the prevalence of SMuRF-less patients among the whole population of individuals with ASCVD in the Middle East.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

A diagnosis of atherosclerotic cardiovascular disease (ASCVD).
Ability to fill the clinical form that evaluates the presence or absence of cardiovascular risk factors including the 4 SMuRFs.

Exclusion criteria

Atherosclerotic cardiovascular disease diagnosed before the age of 18 years.
Inability to give detailed history of prespecified risk factors.

Treatment and study plan

Evaluation of risk factors by direct interview with subjects who have atherosclerotic cardiovascular patients

Other

Individuals identified with a diagnosis of ASCVD will fill a one page form of the associated risk factors they have

Primary outcomes

Prevalence of patients who do not any of the four SMuRFs

Time frame: Up to 4 weeks after study enrollment

Group of patients with definite ASCVD who do not have hypertension, diabetes, dyslipidemia or smoking.

Sponsors and collaborators

Lead sponsor

Jordan Collaborating Cardiology Group

Other

Collaborators

The Jordan Cardiovascular Research Group JoCVRG
Yarmouk University School of Medicine

Registry information

Official study title

Absence of Standard Modifiable Risk Factors Among 5000 Middle Eastern Patients With Atherosclerotic Cardiovascular Disease: Clinical Profiles and Prevalence of Other Risk Factors and Comorbidities

Acronym: SMuRF-less-ME1

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jan 10, 2024
Registry last updated: Feb 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed