Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood

Magnetic resonance imaging (MRI) assessment of cardiac right ventricular mass indexed to body surface area (in g and g/m^2)

MRI assessment of cardiac left ventricular mass indexed to body surface area (in g and g/m^2)

MRI assessment of cardiac right ventricular end-diastolic volume indexed to body surface area (in ml and ml/m^2)

MRI assessment of cardiac right ventricular stroke volume indexed to body surface area (in ml and ml/m^2)

MRI assessment of cardiac left ventricular end-diastolic volume indexed to body surface area (in ml and ml/m^2)

MRI assessment of cardiac left ventricular stroke volume indexed to body surface area (in ml and ml/m^2)

Echocardiography and MRI assessment of right ventricular systolic function: tricuspid annular plane systolic excursion (in cm) and right ventricular ejection fraction measured by cardiac MRI (in %)

Echocardiography and MRI assessment of left ventricular systolic function: left ventricular ejection fraction (in %)

Echocardiography assessment of right ventricular (RV) diastolic function: RV Doppler early/late diastolic tricuspid inflow velocity ratio (E/A)

Echocardiography assessment of left ventricular (LV) diastolic function: LV Doppler early/late diastolic mitral inflow velocity ratio (E/A) and LV early Doppler inflow velocity/peak early diastolic tissue velocity ratio (E/e')

MRI assessment of the right ventricles morphology using cardiac statistical atlas and principal component analysis

MRI assessment of the left ventricles morphology using cardiac statistical atlas and principal component analysis

Aortic distensibility by MRI (in 10^-3 mmHg^-1) and aortic/central blood pressure by cuff measurement (in mmHg)

MRI assessment of the liver to quantify proton density fat fraction (in %) and fibro-inflammatory status from iron-corrected T1 (cT1 in ms)

MRI assessment of fibro-inflammatory status from T1 (in ms) and surrogate measure of blood perfusion from T2* (in ms) and volumes (in ml and ml/m^2)

Cardiopulmonary exercise test to measure oxygen uptake (VO2 in ml/kg/min)

Cardiopulmonary exercise test to measure respiratory exchange ratio (RER calculated as carbon dioxide production divided by oxygen consumption)

Central retinal arteriolar equivalent (CRAE in μm) measured using retinal imaging

Central retinal venular equivalent (CRVE in μm) measured using retinal imaging

The ratio of average retinal arteriolar diameter (CRAE in μm) and average retinal venous diameter (CRVE in μm) measured using retinal imaging

Superior crus of anti-helix earlobe vascular caliber (in μm) measured using ear vascular imaging

The forced expiratory volume in one second (FEV1 in L), forced vital capacity (FVC in L), and the ratio of FEV1 to FVC (FEV1/FVC) measured using spirometry

The amount of moderate to vigorous physical activity (in h/week) and vigorous physical activity (in h/week) measured using wrist worn accelerometer

Total white matter volumes (in mm3) assessed on T1-weighted sequence of brain MRI

Total grey matter volumes (in mm3) assessed on T1-weighted sequence of brain MRI

Subcortical brain volume of thalamus (in mm3) assessed on T1-weighted sequence of brain MRI

Subcortical brain volume of hippocampus (in mm3) assessed on T1-weighted sequence of brain MRI

Total volume of white matter hyperintensities (in mm3) assessed on T2-weighted sequence of brain MRI

The number of white matter hyperintensities on T2-weighted sequence of brain MRI

Cerebral vessel lumen diameter (in μm) assessed on the time-of-flight sequence of brain MRI

Cerebral vessel density (in mm3) assessed on the time-of-flight sequence of brain MRI

The ratio of cerebral vessel tortuosity assessed on the time-of-flight sequence of brain MRI

Whole brain grey matter perfusion/CBF (in ml/100g/min) assessed on arterial spin labelling of brain MRI

Arterial cerebral blood volume fraction (in %) assessed on arterial spin labelling of brain MRI

The level of VEGF-A (in pg/mL) measured from plasma blood samples

The level of sENG (in ng/mL) measured from plasma blood samples

The level of sFlt-1 (in pg/mL) measured from plasma blood samples

The level of total cholesterol (in mmol/L) measured from serum blood samples

The level of HDL (in mmol/L) measured from serum blood samples

The level of LDL (in mmol/L) measured from serum blood samples

The level of triglycerides (in mmol/L) measured from serum blood samples

The level of fasting glucose (in mmol/L) measured from whole blood samples

The level of fasting insulin (in pmol/L) measured from serum blood samples

The index calculated as fasting glucose (in mmol/L) x fasting insulin (in μIU/mL) ÷ 22.5

The level of CRP (in mmol/L) measured from serum blood samples

The level of sICAM-1 (in ng/mL) measured from serum blood samples

The level of sVCAM-1 (in ng/mL) measured from serum blood samples

Body weight measured in kg

Body height measured in m

Body weight divided by the square of height (in kg/m2)

Mid-arm circumference measured in cm

The ratio of waist circumference (in cm) to hip circumference (in cm)

Resting brachial blood pressure measurement (in mmHg)

Resting brachial blood pressure measurement (in mmHg)

The average arterial pressure from resting brachial blood pressure measurement (in mmHg)

The difference between systolic and diastolic blood pressure (in mmHg)

The frequency of the heart contractions per minute (in beats per minute or bpm)

The number and percentage of current smokers

Weekly alcoholic unit intake (in units per week)