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NCT Number: NCT04367220

Cardiovascular Imaging Registry of Canada

A multi-site, multi-modality prospective observational clinical outcomes study focussed on the development of phenotype-dirven risk prediction modelling in patients with known or suspected cardiovascular disease.

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Key information

Conditions

Cardiovascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Foothills Medical Centre, Calgary, Alberta, Canada

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About this study

The Cardiovascular Imaging Registry of Canada (CIROC) was conceived to provide a common standardized architecture for the collection of clinically reported imaging biomarkers, demographic information, resource utilization and clinical outcomes among patients referred to non-invasive cardiac imaging. The Registry was designed to assess the feasibility of implementing personalized care strategies through automated high quality data collection and patient engagement.

The CIROC Registry was launched with inaugural focus on Cardiac MRI base phenotyping, however has evolved to encompass cardiac CTA and echocardiography. Clinically referred patients are engaged by automated, tablet-based tools to collect informed consent and deploy standardized patient health assessments. Standardized reporting of disease features are captured using bespoke reporting tools. All patients are prospectively followed for a period of 10-years using linkage to administrative health data, inclusive of ICD-coded events, laboratory test results, ECG and vital statistics.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients referred for hospital-based cardiac imaging services

Exclusion criteria

  • Failure or provide informed consent

Treatment and study plan

Diagnostic testing performed as per routine care

Diagnostic Test

Primary outcomes

  1. Major adverse cardiovascular outcomes (MACE)

    Time frame: 2024

    Composite of all-cause death, heart failure admission, myocardial infarction, heart transplantation or LVAD, Stroke or TIA

  2. Malignant arrhythmic events

    Time frame: 2024

    Composite of sudden cardiac death or appropriate ICD shock

  3. Heart failure events

    Time frame: 2024

    Composite of heart failure admission, death or need for transplantation / LVAD

  4. Atrial arrhythmic events

    Time frame: 2024

    Occurrence of atrial fibrillation / atrial flutter (documented by 12-lead ECG or Holter monitor)

  5. All-cause mortality

    Time frame: 2024

    Death based on Vital Statistics Alberta and In-hospital coded death

Study contacts

Contact information is provided by the study sponsor or research team.

James White

CONTACT

[email protected]

403-944-2805

Sandra Rivest

CONTACT

[email protected]

403-944-1961

Sponsors and collaborators

Lead sponsor

University of Calgary

Other

Collaborators

  • Alberta Health services

Registry information

Acronym: CIROC

Important dates

Study start
2014
Primary completion
2025
Study completion
2030
First posted
Apr 29, 2020
Registry last updated
Mar 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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