Genetics of Hypertension Associated Treatments (GenHAT)
NCT00006294
Cardiovascular Diseases, Coronary Disease
Lexington, Kentucky, United States
View Trial DetailsNCT Number: NCT00005234
To examine the natural histories of coronary artery disease and hypertension in cohorts of Black and white men of identical education and occupations.
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Notify MeUp to 100 year
Male
Observational
BACKGROUND:
Prior studies of Black-white differences in hypertension and coronary disease have compared racial groups from markedly different socioeconomic and educational backgrounds. This study represented one of a few, if any, long term prospective studies of cardiovascular disease in middle-class Blacks and whites of similar education and occupation, in whom both youthful and midlife risk factors were assessed.
DESIGN NARRATIVE:
In this prospective study, the prevalence and incidence of coronary artery disease, hypertension, and other cardiovascular diseases were compared using standardized endpoint criteria. The prevalence of cardiovascular risk factors in midlife were compared between cohorts, and included smoking, diabetes, family history, dietary factors, and lipoprotein cholesterol levels. The youthful predictors of midlife cardiovascular risk factors were determined using baseline data collected by identical protocols in the two cohorts between 1957 and 1965. The youthful risk factors were related to the incidence of disease in midlife in two cohorts to identify differences in significance, independence, and relative importance of risk factors in Blacks versus whites.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
No eligibility criteria
National Heart, Lung, and Blood Institute (NHLBI)
Nih
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