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Completed

NCT Number: NCT03946215

Cardiorespiratory Responses to Treadmill Running at Different Slopes

The purpose of this study is: i) to determine if maximal oxygen uptake in downhill running is significantly different versus flat or uphill running, and ii) to compare cardiorespiratory and muscle fatigue responses to uphill vs flat and downhill running at similar running velocity and similar metabolic power. The investigators hypothesized that maximal oxygen uptake will be lower in downhill running. The investigators also anticipate attenuated cardiorespiratory and muscle fatigue responses to downhill running when compared to flat or uphill running performed at similar velocity but not when the comparison is done at similar metabolic power.

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Key information

Conditions

Cardiorespiratory Responses Well-trained Athletes

Age range

18 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Les Hôpitaux Universitaires de Strasbourg

Strasbourg, 67091, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • to be a well-trained runner with a VO2max > à 55 ml/kg/min
  • nonsmoker or stopped smoking for 5 years
  • BMI < 25
  • affiliation to the social health insurance scheme
  • signing an informed consent form.

Exclusion criteria

  • impossibility to give the subject enlightened information (subject in emergency situation, difficulties in understanding the study, ...);
  • subject under the protection of justice
  • subject under guardianship or curatorship
  • contraindication to the practice of physical and sport activities
  • lower limbs musculotendinous or articular problems
  • respiratory, cardiovascular or metabolic pathology
  • drug treatment in progress and impossibility to stop it within 7 days before the beginning of the study

Treatment and study plan

Each participant will perform:

Other

Part 1: Maximal incremental tests will require running at fixed slopes (+15%, 0% -15%) for stages (2min duration) of increasing velocities (0.5, 1 and 1.5 km/h) Part two: submaximal running tests will require running at constant velocity (80% VO2max uphill; 80%VO2max downhill and downhill at similar velocity as uphill)

Primary outcomes

  1. Peak oxygen

    Time frame: 15 minutes

    The peak oxygen uptake will be collected during downhill, flat and uphill running

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Comparison of Cardiorespiratory Responses to Treadmill Running at Different Slopes in Well-trained Athletes

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
May 10, 2019
Registry last updated
Oct 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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