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NCT Number: NCT06702059

Cardiopulmonary Exercise Testing in Cardiosurgery Patients

Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery. Surprisingly, only a limited number of studies examined the prognostic role of CPET in cardiothoracic surgery. This is in contrast with rather poor discriminating quality of cardiovascular surgery risk scores and predominantly elderly cardiovascular surgery patients, with significant comorbidity and high degree of frailty. Recently, CPET was shown feasible in coronary artery bypass grafting surgery candidates. Additionally, the rest parameter, which is the partial pressure of end-tidal carbon dioxide (PETCO2) and a submaximal exercise parameter (the VE/VCO2 slope) with good prognostic utility across multiple respiratory exchange ratio values), has been shown to predict mortality and post-operative complications.

Whether these rest and submaximal exercise parameters can be used to predict postoperative complications in cardiovascular surgery patients is yet to be determined.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre of Cardiovascular and Transplantation Surgery, Brno, Czech Republic, Czechia

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients scheduled for coronary artery bypass graft surgery

Exclusion criteria

  • not able to perform cardiopulmonary exercise testing, off-pump revascularization, without full sternotomy, previous cardiac surgery

Treatment and study plan

Cardiopulmonary exercise testing

Diagnostic Test

Subjects will undergo pre-operative cardiopulmonary exercise testing.

Primary outcomes

  1. post-operative pulmonary complications

    Time frame: within 30 post-operative days

    pneumonia, atelectasis, respiratory failure, ARDS

  2. post-operative cardiovascular complications

    Time frame: within 30 post-operative days

    new arrhythmias (atrial fibrillation, supraventricular tachycardia, etc.), myocardial infarction/minimal myocardial lesion, hypotension, heart failure, pulmonary edema, pulmonary embolism, cardiopulmonary resuscitation

Secondary outcomes

  1. Hospital and Intensive care length of stay

    Time frame: within 30 post-operative days

    Hospital and Intensive care length of stay

Study contacts

Contact information is provided by the study sponsor or research team.

Ivan Cundrle, prof., M.D.

CONTACT

[email protected]

00420 543182553

Marek Lukes, M.D.

CONTACT

[email protected]

00 420 543 182 484

Sponsors and collaborators

Lead sponsor

St. Anne's University Hospital Brno, Czech Republic

Other

Collaborators

  • Centre of Cardiovascular and Transplantation Surgery, Czech Republic

Registry information

Official study title

Cardiopulmonary Exercise Testing in the Prediction of Post-operative Complications in Patients Undergoing Coronary Artery Bypass Graft Surgery

Important dates

Study start
2024
Primary completion
2027
Study completion
2028
First posted
Nov 22, 2024
Registry last updated
May 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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