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OpenTrials
Completed

NCT Number: NCT07150754

Cardiological Drug Classes And Falls in Older Adults

Heat failure is a fast gowing health issue with a rising incidence in older adults. Recommendations have recently been published to treat heart failure, but most clinical trials leading to these recommendations tended to exclude older adults.

Older adults are at higher risk of falls and severe consequences of falls. All heart failure treatments are at risk of causing a fall through different mechanisms.

Based on the World Health Organization global database, the main objective of this study is to investigate the association between heart failure pharmacological treatments and the report of a fall in the database.

A disproportionality analysis will be performed. It will aim to assess whether some classes of heart failure drugs, and within these classes some individual drugs, are associated with a report of a fall.

A sensibilty analysis will also be performed. It will aim to examine the association between takien a heart failure pharmacological treatment, with a heat failure indication and/or a loop diuretic, and the report of a fall.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Caen University Hospital, Department of Pharmacology

Caen, Normandy, 14000, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 65 years of older

Exclusion criteria

-

Treatment and study plan

Heart failure pharmacological treatments

Drug

Identify a positive signal for fall with one or more of the recommended pharmacological treatments for heart failure

Primary outcomes

  1. Report of a fall with a recommended pharmacological treatment for heart failure

    Time frame: 02/11/2024

Secondary outcomes

  1. Sensibility analysis

    Time frame: 02/11/2024

    Reports of falls with one or more of the respective drug classes that also had either "furosemide" prescription and/or "heart failure" as indication

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Registry information

Official study title

Heart Failure Pharmacological Treatments and Falls in Older Adults: A Disproportionality Analysis of the WHO Pharmacovigilance Database

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 2, 2025
Registry last updated
Sep 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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