Cardio-Oncology Rehabilitation Care Process

Fall of 10 absolute percentage points of left ventricular ejection fraction from baseline or with final value below 53% or global longitudinal strain fall >15% with respect to baseline

cTnI/T>percentil 99, BNP≥35 pg/mL, NT-proBNP≥125 pg/mL

To estimate VO2peak, the ONCORE equation developed in the following article is used: Díaz-Balboa, E., González-Salvado, V., Rodríguez-Romero, B. et al. Thirty-second sit-to-stand test as an alternative for estimating peak oxygen uptake and 6-min walking distance in women with breast cancer: a cross-sectional study. Support Care Cancer 30, 8251-8260 (2022). https://doi.org/10.1007/s00520-022-07268-z

Dyslipidemia, Diabetes mellitus, Arterial Hypertension, Smoking status

Value of fasting blood glucose (mg/dL) in blood tests

Value of LDL >160 mg/dL or CT> 200 mg/dL in blood tests

Value of haemoglobin (g/dL) in blood tests

number of participants with significant cardiovascular and non-cardiovascular adverse effects throughout the study, threatening life, requiring admission, prolonging hospitalization, being clinically relevant or causing chemotherapy interruptions.

Score achieved in the Functional Assessment of Cancer Therapy - Breast plus Arm Morbidity (FACT-B+4) questionnaire, a specific validated scale to assess quality of life of women with breast cancer. It comprises 27 items within 5 areas of assessment: physical well-being (7 items), social and family environment (7 items), emotional well-being (7 items), functional well-being (6 items) and worries related to the diagnosis and treatment of the disease (9 items). Each item is scored by means of a Likert scale from 0 to 5, with higher scores representing better results. The total score is obtained by adding the scores for each item, and ranges from a minimum of 0 (worst possible result) to a maximum of 146 (best possible result).

Number of repetitions in the sit-to-stand test within 30 seconds.

Kilograms by dynamometry.

Kilograms by dynamometry.

Thigh perimeter measured with a tape measure in cm.

The peak expiratory flow in units of liters per minute (L/min), measured with a peak flow meter.

Grip strength (both right and left side) and bilateral biceps strength in kilograms by dynamometry.

Weight measured in kg.

Weight and height will be combined to report BMI in kg/m^2

Abdominal perimeter measured with a tape measure in cm.

Resting heart rate by pulse oximetry (beats per min).

Resting blood pressure by a blood pressure monitor in mmHg.

Score achieved in the Godin Leisure Test Exercise Questionnaire (GLTEQ) for quantification of physical activity. Activities are classified into three subgroups: "strenuous," "moderate," and "light." The scores corresponding to the energy expenditure (metabolic equivalent (MET)) are obtained by multiplying activities performed for more than 15 min in a week with their coefficients. The numbers represent the MET intensity values (strenuous/ exhausting exercises: 9 METs, moderate exercises: 5 METs, and light exercises: 3 METs).The increasing scores are associated with the increasing number of exercise behaviors, providing references about the contribution of physical activity to health: the activity score of 24 units and more as active (substantial benefits); the activity score of 14-23 units as moderately active (some benefits); and the activity score of 13 units and less as inactive (less substantial or low benefits).

ACE Inhibitor/ARB II; Beta-blocker; Statins; Ezetimibe

Number of training sessions attended / number of sessions planned.

Number of telephone calls attended / number of telephone calls planned.

Adverse events during training.

Global satisfaction is scored from 0 (no benefit) to 10 (highest benefit); and evaluated with an open-ended question, how do you expect to benefit from participating in the program?

Question (yes/no): do you continue exercising? supervized? if supervized, is it individualized by a physiotherapist? individualized by a personal trainer? recommendations from a technician in a gym? or city council group activities?

It is considered 2 cm difference between upper limbs. Measurement is performed at the base of the 3rd finger, hand, wrist, 10 cm above the wrist, elbow, 10 cm above the elbow and axilla.