Cardiac Uptake of Metformin, Visualized by Positron Emission Tomography

The purpose of the study is to evaluate if metformin is taken up into the failing myocardium. Recent experimental and epidemiological studies have shown beneficial effects of metformin on heart failure. It is unknown whether this effect is direct or indirect.

The aim of the study is to investigate if metformin is taken up in heart failure using a novel 11C-metformin tracer and positron emission tomography (PET).

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Key information

Conditions

Heart Failure, Systolic Cardiovascular Diseases Heart Diseases Heart Failure

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Aarhus University Hospital, Department of Cardiology, Palle Juul-Jensens Boulevard 99

Aarhus N, 8200, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with chronic heart failure, Left Ventricular Ejection Fraction <45%
New York Heart Association (NYHA) class I, II, III
Relatively preserved renal function (eGFR > 30 ml/min)
Ability to understand the written patient information and to give informed consent
Negative p-HCG for women of childbearing potential

Exclusion criteria

Known allergy to metformin
Age < 18 years
Current abuse of alcohol or drugs

Treatment and study plan

11C-metformin

Radiation

200 MBq of 11C-metformin is injected in the cubital vein. The participant is then scanned for 120 min using Positron Emission Tomography

Primary outcomes

Metformin uptake in the failing myocardium

Time frame: 12 months

Cardiac uptake is evaluated through analysis of acquired PET-images.

Sponsors and collaborators

Lead sponsor

Henrik Wiggers

Other

Registry information

Official study title

Cardiac Uptake of Metformin and Expression of Metformin Membrane Transporter Proteins in the Human Failing Myocardium

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Apr 21, 2017
Registry last updated: Apr 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed