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NCT Number: NCT07375264

Cardiac Sympathetic Denervation in Patients With Refractory Arrhythmic Storm: a Single-center Case Series

The objective of our study was to evaluate the effectiveness of stellate ganglion block (SGB) and of the bilateral cardiac sympathetic denervation (BCSD) in patients with electrical storm refractory to conventional treatment..

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Key information

Conditions

Ventricular Arrhythmias Electrical Storm Stellate Ganglion Block

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

FINBA

Oviedo, Principality of Asturias, 33001, Spain

About this study

A prospective, single-center observational study was designed with the aim of evaluate the safety and short-term efficacy of SGB within the first 24 hours, as well as the long-term effectiveness of ultrasound-guided percutaneous BCSD at 12 months, in patients with refractory electrical storm.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients over 18 years of age.
  • arrhythmic storm refractory to conventional treatment.

Exclusion criteria

  • patients younger than 18 years of age.
  • previous history of heart transplantation.
  • history of previous surgical cardiac sympathetic denervation.
  • patients with neck anatomy considered unsuitable for the procedure (including previous neck surgery, burns, the presence of extensive scars, or large goiters with significant displacement of adjacent structures).
  • contraindications to the interventional technique (such as infection at the puncture site, or refusal to provide consent).

Treatment and study plan

Cardiac sympathetic denervation.

Procedure

Patients underwent stellate ganglion block with 10 ml of levobupivacaine 0.25% and subsequently ultrasound-guided percutaneous bilateral cardiac sympathetic denervation , two neuroablative lesions were created using conventional radiofrequency treatment at 60°C, 20 V for 90 seconds.

Primary outcomes

  1. Arrhythmic burden.

    Time frame: The arrhythmic burden was assessed both in the early period (first 24 hours following SGB) and in the long term (during the 12 months following BCSD).

    The arrhythmic burden was quantified by the number of sustained ventricular arrhythmias, antitachycardia pacing (ATP) therapies, and ICD (implantable cardioverter-defibrillator) shocks recorded during the follow-up period.

Sponsors and collaborators

Lead sponsor

Jose Manuel López González

Other

Registry information

Official study title

Long-term Outcomes of Ultrasound-guided Percutaneous Bilateral Cardiac Sympathetic Denervation in Patients With Refractory Arrhythmic Storm: a Single-center Case Series

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jan 29, 2026
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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