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Completed

NCT Number: NCT07006441

Cardiac Rehabilitation in Coronary Artery Bypass Graft Surgery

This randomized controlled trial investigates the comparative effects of a combined preoperative and postoperative cardiac rehabilitation program versus a postoperative-only program on functional capacity, pulmonary function, peripheral muscle strength, pain, kinesiophobia, and quality of life in patients undergoing coronary artery bypass graft (CABG) surgery. The study aims to determine whether initiating rehabilitation prior to surgery improves short-term postoperative outcomes.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul Atlas University

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Having undergone coronary artery bypass graft surgery
  • Ejection Fraction (EF) > 40%
  • Being between the ages of 18-65
  • Being able to speak, read and understand in their own language
  • Volunteering to participate in the study

Exclusion criteria

  • Having an active or suspected infection
  • Presence of an active tumour
  • History of thrombophlebitis or pulmonary embolism within the last 3 months
  • Having an orthopaedic, neurological or cardiovascular disease that may affect the assessments

Treatment and study plan

Preoperative Cardiac Rehabilitation

Other

Structured exercise program, respiratory physiotherapy, and patient education

Postoperative Cardiac Rehabilitation

Other

Structured exercise program, respiratory physiotherapy, and patient education

Primary outcomes

  1. Forced Vital Capacity (FVC)

    Time frame: 2 weeks

    Forced Vital Capacity will be measured before six-minute walk test according to the guideline of ERS.

  2. Forced Expiratory Volume in 1 second (FEV1)

    Time frame: 2 weeks

    Forced Expiratory Volume in 1 second will be measured before six-minute walk test according to the guideline of ERS.

  3. Peak Expiratory Flow (PEF)

    Time frame: 2 weeks

    Peak Expiratory Flow will be measured before six-minute walk test according to the guideline of ERS.

  4. Forced Expiratory Flow 25-75% (FEF25-75)

    Time frame: 2 weeks

    Forced Expiratory Flow 25-75% will be measured before six-minute walk test according to the guideline of ERS.

  5. 6-minute Walk Test

    Time frame: 2 weeks

    The 6-minute Walk Test will be performed according to ATS guidelines. Walking distance, minute ventilation, respiratory rate, inspiratory capacity and breathing reserve will be recorded.

  6. M. Quadriceps Muscle Strength

    Time frame: 2 weeks

    The m. quadriceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.

  7. M. Biceps Muscle Strength

    Time frame: 2 weeks

    The m. biceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.

  8. Cough Peak Flow

    Time frame: 2 weeks

    Cough Peak Flow (CPF) will be measured using a peak expiratory flow meter. Participants will be instructed to take a maximal deep breath and then cough as forcefully as possible into the device; the highest value from three trials will be recorded in liters per minute (L/min). Measurements will be performed in a seated position, ensuring a tight mouth seal and consistent technique.

Secondary outcomes

  1. Level of Pain

    Time frame: 2 weeks

    Pain assessment will be performed using the Visual Analog Scale (VAS) to evaluate chest pain levels. Participants will be asked to mark their current pain intensity on a 10 cm horizontal line, with "no pain" at one end and "worst imaginable pain" at the other. The distance in centimeters from the "no pain" end to the mark will be measured and recorded as the pain score.

  2. Level of Fear of Movement

    Time frame: 2 weeks

    Fear of movement (kinesiophobia) will be assessed using the Tampa Scale for Kinesiophobia (TSK). Participants will complete the 17-item questionnaire, which evaluates fear of movement and re-injury on a 4-point Likert scale. The total score, ranging from 17 to 68, will be calculated, with higher scores indicating greater fear of movement.

  3. Level of Quality of Life

    Time frame: 2 weeks

    Quality of life will be assessed using the Short Form-36 (SF-36) Health Survey. Participants will complete the 36-item questionnaire, which evaluates eight domains including physical functioning, bodily pain, general health, and mental well-being. Each domain will be scored from 0 to 100, with higher scores indicating better perceived quality of life.

Sponsors and collaborators

Lead sponsor

Atlas University

Other

Registry information

Official study title

The Effects of Preoperative and Postoperative Cardiac Rehabilitation in Patients Undergoing Coronary Artery Bypass Graft Surgery

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jun 5, 2025
Registry last updated
Aug 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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