Skip to main content
OpenTrials
Completed

NCT Number: NCT04524234

Cardiac Dysfunction in Critically Ill Patients With COVID-19

Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients infected with COVID-19.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Covid19 COVID-19 Cardiovascular Diseases Coronaviridae Infections Coronavirus Infections Heart Diseases Hypertension Hypertension, Pulmonary Infections Left Ventricular Dysfunction Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral Pulmonary Hypertension RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Right Ventricular Dysfunction Vascular Diseases Ventricular Dysfunction Ventricular Dysfunction, Left Ventricular Dysfunction, Right Virus Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Södersjukhuset, Stockholm, Region Stockholm, Sweden

Loading trial locations.

About this study

Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients with COVID-19. Patients admitted to the intensive care unit, with COVID-19 are examined with echocardiography for assessment of left and right ventricular dysfunction within 72 hours from admission and repeated after four to seven days.

Cardiac dysfunction was defined as having either left ventricular (LV) dysfunction, defined as having an ejection fraction <50% and/or regional hypokinesia, or right ventricular (RV) dysfunction, defined as having a tricuspid annular plane excursion (TAPSE) <17mm or a moderate/severe RV dysfunction assessed visually.

The cardiac biomarkers troponin and NTproBNP and clinical data are recorded at time of each echo. Mortality status is recorded at 30 days.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients admitted to the intensive care unit infected with COVID-19

Exclusion criteria

-

Treatment and study plan

Echocardiography

Diagnostic Test

Echocardiography for assessment of cardiac function

Primary outcomes

  1. Mortality

    Time frame: 30 days

    All cause death in patients with vs without cardiac dysfunction

Secondary outcomes

  1. Left ventricular dysfunction

    Time frame: Within 72 hours from admission

    Prevalence of left ventricular dysfunction

  2. Right ventricular dysfunction

    Time frame: Within 72 hours from admission

    Prevalence of right ventricular dysfunction

  3. Risk-factors

    Time frame: Within 72 hours from admission

    Clinical variables associated with risk of having cardiac dysfunction

  4. Cardiac biomarkers

    Time frame: Within 72 hours from admission

    Levels of cardiac biomarkers in patients with vs without cardiac dysfunction

  5. Left ventricular dysfunction

    Time frame: During ICU-stay

    Prevalence of left ventricular dysfunction

  6. Right ventricular dysfunction

    Time frame: During ICU-stay

    Prevalence of right ventricular dysfunction

  7. Risk-factors

    Time frame: During ICU-stay

    Clinical variables associated with risk of having cardiac dysfunction

  8. Cardiac biomarkers

    Time frame: During ICU-stay

    Levels of cardiac biomarkers in patients with vs without cardiac dysfunction

Sponsors and collaborators

Lead sponsor

Sahlgrenska University Hospital

Other

Registry information

Acronym: CARDYCOVID

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Aug 24, 2020
Registry last updated
Dec 24, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.