NCT Number: NCT03790943
This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking echocardiography as novel echocardiographic technique compared to conventional echocardiography.
Interested in participating?
Request Info18 year and older
All sexes
Observational
Department of Cardiology, University Hospital Basel, Basel, Canton of Basel-City, Switzerland
Cardiovascular disease including cardiac dysfunction is the leading non-malignant cause of death in childhood cancer survivors. Early detection of cardiac dysfunction is important to identify those in need for medical intervention to improve outcome. This study invites adult childhood cancer survivors to a clinical appointment to the University Hospital Bern, Switzerland. A detailed, standardized cardiac assessment including conventional and novel echocardiographic techniques (speckle tracking) as well as cardiopulmonary exercise testing is performed. Cardiac dysfunction is evaluated in survivors who have had cardiotoxic cancer therapy with anthracyclines and/or chest radiation (high risk) and in survivors who have had chemotherapy other than anthracyclines (standard risk).
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis.
Inclusion criteria
Exclusion criteria
Personal history, physical examination including anthropometry with hip/waist-ratio, electrocardiogram, echocardiography, 1-minute-sit-to-stand test, questionnaires on health-related quality of life (SF-36), diet, physical activity, and fatigue
Time frame: Baseline and longitudinal follow-up where clinically indicated
Conventional echocardiography: left ventricular ejection fraction (%)
Time frame: Baseline and longitudinal follow-up where clinically indicated
Speckle tracking echocardiography: longitudinal (LS), circumferential (CS), and radial strain (RS)
Time frame: Baseline
Cardiopulmonary exercise testing: peak oxygen consumption, percent-predicted carbon dioxide production
Time frame: Baseline
Cumulative doses of anthracyclines, steroids, and alkylating agents (mg/m2)
Time frame: Baseline
Dose of chest radiation (Gray)
Contact information is provided by the study sponsor or research team.
Christina Schindera, MD
CONTACT
Claudia E Kuehni, MD
CONTACT
University of Bern
Other
Prospective Single Center Cohort Study for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
Acronym: Cardio-Onco
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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