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Completed

NCT Number: NCT01534000

Cardiac-CT in the Treatment of Acute Chest Pain

Objectives The CATCH trial (CArdiac cT in the treatment of acute CHest pain) is a prospective randomized controlled trial designed to evaluate the clinical value of cardiac multidetector computed tomography (MDCT) as a first-line diagnostic strategy in patients with acute chest pain, compared to a conventional functional-based testing strategy.

Methods:

Consecutive patients admitted with acute chest pain of suspected cardiac origin, but normal electrocardiogram and biomarkers were randomized to evaluation with 320-MDCT coronary angiography (CT-guided group) or with standard bicycle exercise test and/or myocardial perfusion imaging - MPI (Control group).

After one year, patients will be followed-up, with registration of clinical endpoints such as Cardiac death, myocardial infarction, need for revascularisation, admittance for heart related problems, sustained chest pain, live quality score, use of medication.

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Key information

Conditions

Ischemic Heart Disease Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hvidovre University Hospital

Hvidovre, 2650, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Admittance because of Chest pain
  • Non- or non-diagnostic ecg-changes.
  • Normal biomarkers for ischemia (Troponins)
  • Chest X-ray without pathological findings associated with chest pain.

Exclusion criteria

  • Women of childbearing age, or > 40 years and using approved contraception.
  • Claustrophobia
  • Patients with geographical residence, that complicates follow-up
  • Patients with mental or physical conditions that impede follow-up
  • Increase in Troponins
  • New diagnostic ECG changes with ST-segment elevation or depression greater than 1mm or T-yew inversion> 4 mm in> 2 anatomically connected derivations.
  • Allergy to iodinated contrast agents
  • Serum creatinine greater than 130 mg/l
  • Abnormal chest x-ray or blood tests hospitalization as assessed as the main cause of the patient's pain problem.

Treatment and study plan

Cardiac computed tomographic angiography (CCTA)

Procedure

Patients will (on top of the standard clinical evaluation with a functional-based stress-test) be examined with a Cardiac CT scan. In the control group, the Cardiac CT will be blinded for clinical evaluation and only used retrospectively for research purpose.

Other names: Adenosin for CT myocardial perfusion

Primary outcomes

  1. combined endpoint of: Cardiac death, myocardial infarction, unstabile angina, revascularisation, readmissions for chest pain

    Time frame: 1 year follow-up

Secondary outcomes

  1. Cardiac death

    Time frame: 1 year follow-up

  2. myocardial infarction

    Time frame: 1 year follow-up

  3. readmissions for chest pain

    Time frame: 1 year follow-up

  4. Revascularisation

    Time frame: 1 year follow-up

  5. unstabile angina

    Time frame: 1-year follow-up

  6. continued chest pain

    Time frame: 1 year follow-up

  7. Quality of life (SF-36)

    Time frame: 1-year follow-up

  8. medication

    Time frame: 1-year follow-up

  9. non-cardiac findings on CT

    Time frame: 1-year follow-up

  10. downstream testing

    Time frame: 1-year follow-up

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Registry information

Acronym: CATCH

Important dates

Study start
2010
Primary completion
2014
Study completion
2014
First posted
Feb 16, 2012
Registry last updated
Jun 19, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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