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NCT Number: NCT07320261

Cardiac CT Evaluation of EAT in AF vs. Non-AF Subjects

The goal of this cross-sectional study is to explore the relationship between atrial structural characteristics (such as epicardial adipose tissue infiltration and atrial size) and atrial fibrillation (AF), as well as the differences in these characteristics among different AF subtypes. It will also clarify the independent association between pericardial fat distribution and AF (and its subtypes) after excluding confounding factors.

The main questions it aims to answer are:

* What are the differences in epicardial adipose tissue volume and atrial size among patients with sinus rhythm, paroxysmal AF, and persistent AF? * Is pericardial fat distribution independently associated with AF and its subtypes after adjusting for confounding factors such as age, hypertension, and left atrial enlargement?

Researchers will enroll patients who undergo coronary CTA or left atrial CTA at The Second Affiliated Hospital of Zhejiang University School of Medicine, and match and divide them into three groups (sinus rhythm group, paroxysmal AF group, and persistent AF group) based on BMI and other factors. They will compare the differences in pericardial fat distribution and baseline characteristics among the three groups and analyze the independent association between pericardial fat and AF.

Participants will:

* Provide relevant clinical baseline data and CTA examination results * Complete the collection of demographic information, medical history, and laboratory test data

The study duration is 6 months, starting from the date of ethical approval, with an expected end date of June 2026. A total of 600-900 participants (200-300 per group) will be enrolled to ensure the reliability and clinical applicability of the research conclusions.

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Key information

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who undergo coronary CTA or left atrial CTA examination at The Second Affiliated Hospital of Zhejiang University School of Medicine;
  • Aged 18 years or older
  • Cardiac rhythm status is confirmed as sinus rhythm, paroxysmal atrial fibrillation, or persistent atrial fibrillation;
  • Willing to provide clinical baseline data and allow access to CTA examination results;
  • Able to understand and cooperate with the data collection process of the study.

Exclusion criteria

  • Patients with incomplete clinical baseline data or unreadable CTA images;
  • Aged less than 18 years
  • Patients who refuse to participate in the study or cannot cooperate with data collection;
  • Other situations judged by the researchers to be unsuitable for inclusion in the study.

Treatment and study plan

Primary outcomes

  1. The difference in epicardial adipose tissue distribution among the three cohorts

    Time frame: At the time of enrollment

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaoya Wang, Doctor

CONTACT

[email protected]

86-0571-87784704

Sponsors and collaborators

Lead sponsor

xiaoya wang

Other

Collaborators

  • University of Auckland, New Zealand

Registry information

Official study title

Cardiac Computed Tomography Evaluation of Epicardial Adipose Tissue Differences Between Patients With Atrial Fibrillation and Non-Atrial Fibrillation Individuals

Acronym: CCT-EAT-AF-NA

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 6, 2026
Registry last updated
Jan 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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