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Completed

NCT Number: NCT02937415

Carbon Monoxide and Oxidative Stress in Waterpipe Smokers

Waterpipe is a tool for smoking tobacco, which is thought to be less harmful than cigarette. Unfortunately, there aren't adequate studies about its harms to health that are threatening the young generation all over the world today. The objective of this study was to show the carbon monoxide (CO) levels in waterpipe smokers' breaths, whether can be used or not to reflect the changes of oxidative stress for this reason to predict harmful effects on the pulmonary functions.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Waterpipe or hookah uses a different kind of tobacco, which is available in most Balkan countries, Middle East and South Asia. Popularity of smoking waterpipe among European, Canadian, and American young people has shown a dramatic rise over the past decade. The growing popularity of waterpipe use among U.S. teens and adults is evidenced by media reports and the recent rapid proliferation of waterpipe establishments (bars, cafes, or restaurants) in large cities and near college campuses. Typical waterpipes have the following components; a bowl where the tobacco is placed and heated, usually with burning embers or charcoal, a vase or smoke chamber which is partially filled with water, a pipe or stem connecting the bowl to the vase by a tube that carries the smoke down into the water, and a hose with a mouthpiece through which the smoke is drawn from the vase. As the smoker inhales, the tobacco smoke is sucked down from the bowl and then bubbles up through the water into the air of the smoke chamber and then through the hose to the smoker. At the end of a smoking session, the dirty water is thrown away and the waterpipe vase is refilled for the next user. Although each smoking session generally lasts about 45 to 60 minutes, it can also continue for several hours.

There is a misconception about smoking waterpipe that it is less harmful than cigarettes, and that's why smoking waterpipe is dramatically increasing especially among young people. While the adverse effects of smoking cigarette are widely described, there are just a few investigations about waterpipe and its effects. This study was designed to investigate the effects of smoking waterpipe on pulmonary functions and oxidative stress parameters.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants who haven't determined major health problems,
  • between ages 18-40.

Exclusion criteria

  • Participants who under age 18 and above 40,
  • pregnant women,
  • individuals who have major health problems

Treatment and study plan

Breath carbon monoxide

Procedure

Breath carbon monoxide measurement.

Pulmonary function tests.

Procedure

Measurement of lung functions by blowing through a tube which measures flow and volumes of participant's lungs.

Other names: Spirometry

Oxidative stress and antioxidant status.

Procedure

Measurement of parameters of oxidative stress and antioxidant status in blood samples.

Primary outcomes

  1. Breath Carbon Monoxide Level

    Time frame: Up to 4 months

    Levels of CO in breath will be measured in either waterpipe smokers or control group.

Secondary outcomes

  1. A spirometric Test; FEV1 (Forced Expiratory Volume in One Second) Measurement.

    Time frame: Up to 4 months

    FEV1 Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.

  2. A spirometric Test; FVC (Forced Vital Capacity) Measurement.

    Time frame: Up to 4 months

    FVC Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.

  3. A spirometric Test; FEV1/FVC (Forced Expiratory Volume in One Second/Forced Vital Capacity) Measurement.

    Time frame: Up to 4 months

    FEV1/FVC Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.

  4. A spirometric Test; PEF (Peak Expiratory Flow) Measurement.

    Time frame: Up to 4 months

    PEF Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.

  5. A spirometric Test; FEF25-75 (Forced Expiratory Flow in 25-75%) Measurement.

    Time frame: Up to 4 months

    FEF25-75 Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.

  6. Plasma TAS (Total Anti-Oxydant Status) Measurement.

    Time frame: Up to 4 months

    To Assessment of Anti-Oxidant Status: TAS Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.

  7. Plasma TOS (Total Oxydative Stress) Measurement.

    Time frame: Up to 4 months

    To Assessment of Oxidative Stress: TOS Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.

  8. Plasma OSI Measurement.

    Time frame: Up to 4 months

    To Assessment of Antioxidant Status: TAS (Total Anti-oxydative Status) Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.

  9. Plasma PON (Paraoxonase) Measurement.

    Time frame: Up to 4 months

    To Assessment of Antioxidant Status: PON Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.

  10. Plasma sPON (Stimulated Paraoxonase) Measurement.

    Time frame: Up to 4 months

    To Assessment of Antioxidant Status: sPON Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.

  11. Plasma ARES (Arylesterase) Measurement.

    Time frame: Up to 4 months

    To Assessment of Arylesterase Activity: ARES Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.

Sponsors and collaborators

Lead sponsor

Ataturk Training and Research Hospital

Other

Registry information

Official study title

Breath Carbon Monoxide Measurement Predicts Oxidative Stress Which Cause of Deteriorations of Lung Functions in Waterpipe Smokers

Important dates

Study start
2012
Primary completion
2012
Study completion
2013
First posted
Oct 18, 2016
Registry last updated
Oct 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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