Carbon Dioxide Infusion:Clinical and Histological Appraisal in Chronic Wounds

Carbon dioxide infusion is a non surgical procedure applied via percutaneous, transdermal and subcutaneous. Increase in the concentration of carbon dioxide decreases pH activating local nitric oxide that stimulates collateral vessels formation, vascular endothelial growth factor and basic fibroblast growth factor. Carbon dioxide infusion restores the blood flow in chronic wounds of the lower limbs.

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Key information

Conditions

Wounds Wounds and Injuries

Age range

49 year–59 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Instute of Assistance in Plastic Surgery of São Paulo

São Paulo, 04006-052, Brazil

About this study

Ten patients with chronic wounds caused by venous insufficiency at both lower limbs were distributed into groups. Group I was composed by wounds in the right lower limb that received carbon dioxide and group II by wounds in the left lower limb that not received carbon dioxide, both related to the same patient. Carbon dioxide infusion was performed with the needle pointed toward the granulation tissue, 5cm distant from each one at intervals of 4 days. Biopsies were collected from the wounds before carbon dioxide infusion and after the 3rd, 5th and 10th application. Statistical analysis of the data was performed using Wilcoxon's test and Friedman's variance analysis and multiple comparisons test.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

chronic wounds caused by venous insufficiency

Exclusion criteria

other diseases of the lower limbs

Treatment and study plan

Primary outcomes

dilatation of peripheral blood vessels, number of capillaries, macrophages and fibroblasts

Time frame: 10 sessions (5 weeks) per patient

Sponsors and collaborators

Lead sponsor

Institute of Assistance in Plastic Surgery, Sao Paulo

Other

Registry information

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2008
First posted: May 30, 2013
Registry last updated: May 30, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed