Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07661446

Cannabis and Opioid Use Disorder, Study 2

This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks. During this time, we will examine how repeated doses of oral cannabis and acute doses of oral and inhaled cannabis 1) modify the intensity and time course of opioid withdrawal, 2) modify the effects of intranasal opioid administration and 3) impact the safety of opioid administration.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Opioid Use Disorders Cannabis Use Chemically-Induced Disorders Marijuana Abuse Mental Disorders Narcotic-Related Disorders Opioid-Related Disorders Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

University of Kentucky

Lexington, Kentucky, 40508, United States

Location contact

Paul Nuzzo

CONTACT

[email protected]

859-323-0002

Shanna Babalonis, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants with moderate to severe opioid use disorder

Exclusion criteria

  • Individuals who do not use opioids or do not experience opioid withdrawal when they stop using opioids

Treatment and study plan

Inhaled Cannabis

Drug

Participants will receive inhaled cannabis and placebo

Intranasal Opioid

Drug

Participants will receive intranasal opioids and placebo

Primary outcomes

  1. Opioid withdrawal severity

    Time frame: This outcome will be assessed regularly from baseline through 6 hours post cannabis dose during experimental sessions.

    Opioid severity is a participant-rated outcome that will be measured on a visual analog scale (0-100)

Study contacts

Contact information is provided by the study sponsor or research team.

Paul Nuzzo

CONTACT

[email protected]

859-323-0002

Sponsors and collaborators

Lead sponsor

University of Kentucky

Other

Registry information

Important dates

Study start
2026
Primary completion
2029
Study completion
2030
First posted
Jun 22, 2026
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.