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NCT Number: NCT07160153

Cannabis Abstinence and Neurocognitive Assessment in Adolescence

Cannabis Abstinence and Neurocognitive Assessment in Adolescence

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Key information

Conditions

Cannabis Dependence Chemically-Induced Disorders Cognitive Assessment Harmful Use Marijuana Abuse Mental Disorders Substance-Related Disorders

Age range

15 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Evaluate the development of cognitive functions following attainment of abstinence in a group of adolescents with cannabis dependence or harmful cannabis use. Abstinence is confirmed by toxicological testing.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adolescents aged 15-18 years with a diagnosis of cannabis dependence or harmful cannabis use.

Exclusion criteria

  • psychiatric comorbidity - Dual diagnosis, including psychotic disorders, mood disorders, severe organic brain damage, or autism spectrum disorder, with the exception of compensated and stabilized anxiety disorder. Psychopharmacological treatment is permitted, except for antipsychotics prescribed for psychosis.
  • somatic comorbidity - Severe endocrine disorders such as diabetes mellitus, thyroid dysfunction, or severe cardiovascular disease.
  • Violation of abstinence between the first and second neuropsychological assessments, as well as severe decompensation of mental state requiring modification of established psychopharmacological treatment.

Treatment and study plan

Neurocognitive assessment

Diagnostic Test

Neurocognitive battery:

TMT-Trail Making Test Auditory Verbal Learning Test Stroop Test Tower of London (ToL), Shallice version Continuous Performance Test-Identical Pairs

Other psychometrics:

The level of dependence is quantified using the CAST (Cannabis Abuse Screening Test)

Urine toxicological assessment

Diagnostic Test

Urine toxicological assessment

Primary outcomes

  1. Change in performance TMT-B

    Time frame: 8 weeks

    Change in performance on the Trail Making Test - Part B (TMT-B) [Time Frame: after 8 weeks of abstinence from cannabis]

Secondary outcomes

  1. Change in performance on AVLT

    Time frame: 8 weeks

    Change in performance on the Auditory Verbal Learning Test (AVLT) [Time Frame: after 8 weeks of abstinence]

  2. Change in performance on the Stroop Test

    Time frame: 8 weeks

    Change in performance on the Stroop Test [Time Frame: after 8 weeks of abstinence]

  3. Change in performance on the Tower of London

    Time frame: 8 weeks

    Change in performance on the Tower of London (Shallice version) [Time Frame: after 8 weeks of abstinence]

  4. Change in performance on CPT-IP

    Time frame: 8 weeks

    Change in performance on the Continuous Performance Test - Identical Pairs (CPT-IP) [Time Frame: after 8 weeks of abstinence]

Other outcomes

  1. Cannabis Abuse Screening Test versus degree of neurocognitive impairment

    Time frame: 8 weeks

    Correlation between severity of cannabis dependence (Cannabis Abuse Screening Test, CAST) and degree of neurocognitive impairment [Time Frame: baseline and after 8 weeks of abstinence]

Study contacts

Contact information is provided by the study sponsor or research team.

Frantisek Nekvapil, MD

CONTACT

[email protected]

+420 377 103 101

Jiri Podlipny, MD, Ph.D.

CONTACT

[email protected]

+420 377 103 209

Sponsors and collaborators

Lead sponsor

University Hospital Pilsen

Other

Registry information

Acronym: CANAA

Important dates

Study start
2024
Primary completion
2028
Study completion
2029
First posted
Sep 8, 2025
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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