Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT02407808

Cannabinoids, Learning, and Memory

The overarching goal of this study is to characterize the effects of cannabinoids on working and episodic memory.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Cannabis Chemically-Induced Disorders Marijuana Abuse Mental Disorders Psychotic Disorders Schizophrenia Spectrum and Other Psychotic Disorders Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

VA Connecticut Healthcare System

West Haven, Connecticut, 06516, United States

About this study

This study will be achieved by studying the acute effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis and a cannabinoid-1 receptor (CB1R) agonist, on a wide range of memory tasks in healthy human subjects.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women aged 18 and 55 years (extremes included) on day of first dosing
  • Exposed to cannabis at least once in their lifetime

Exclusion criteria

  • Cannabis naive
  • Positive pregnancy screen during screening
  • Hearing deficits

Treatment and study plan

THC

Drug

Active THC (0.0015-0.03 mg/kg) administered over 20 minutes.

Placebo

Drug

Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.

Primary outcomes

  1. Rey Auditory Verbal Learning Test (RAVLT)

    Time frame: +35 minutes after infusion

    a measure of verbal episodic memory

  2. N-Back Task

    Time frame: +65 minutes after infusion

    a measure of working memory

Secondary outcomes

  1. Clinician Administered Dissociative Symptoms Scale (Total Score)

    Time frame: Baseline, +10, +85, and +240 minutes after the first infusion

  2. Visual Analog Scale (Total Score)

    Time frame: Baseline, +10, +85, +240 minutes after the first infusion

    a measure of THC intoxication

Sponsors and collaborators

Lead sponsor

Yale University

Other

Registry information

Acronym: THC-Memory

Important dates

Study start
2015
Primary completion
2018
Study completion
2027
First posted
Apr 3, 2015
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.