Candidate Gene Association Study With Injury in Elite Male Youth Football Players

Understanding how candidate genes, previously associated with injury susceptibility, influence the incidence of muscle, bone, ligament, and tendon injuries across the development pathway of elite footballers may provide valuable insight into inherent injury predisposition to support the long-term development of every individual. Therefore, the aim of the present study was to investigate the association between candidate genetic variants and muscle, bone, ligament, and tendon injuries in elite football with sub-analysis of the influence of age and maturation on injury susceptibility.

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Key information

Conditions

Injuries Fractures, Bone Genetic Change Sprains and Strains Wounds and Injuries

Age range

8 year–40 year

Sex eligibility

Male

Study type

Observational

Primary location

Fulham Football Club, London, New Malden, United Kingdom

About this study

Genetic variants in several candidate genes which code for structural constituents (COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722 and ACTN3 rs1815739), regulatory components (ACE rs1799752, ESR1 rs2234693 and MMP3 rs679620) and transcription factors (VDR rs2228570 and GDF5 rs143383) affecting the form, function and injury susceptibility of muscle, bone, ligament, and tendon tissue will be associated with overall injury, non-contact, bone, ligament, tendon and apophysitis injury risk in elite male youth and adult footballers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Elite Male Footballer Player Registered at Fulham Football Club

Exclusion criteria

Female no longer registered at Fulham Football Club

Treatment and study plan

Genetic variants

Genetic

COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722, ACTN3 rs1815739, ACE rs1799752, ESR1 rs2234693, MMP3 rs679620, VDR rs2228570 and GDF5 rs143383

Primary outcomes

Number of non-injured and injured participants with injury risk alleles

Time frame: 8 Years

Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury

Sponsors and collaborators

Lead sponsor

St Mary's University College

Other

Collaborators

Fulham Football Club

Registry information

Official study title

Candidate Gene Association Study With Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury in Elite Male Youth Football Players

Important dates

Study start: 2019
Primary completion: 2021
Study completion: 2021
First posted: Jul 7, 2021
Registry last updated: Jul 7, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed