"Cancersensor": Circadian Rhythms

Inclusion criteria

for patients:

• Histologically-confirmed metastatic colorectal cancer;
• 0 to 3 prior chemotherapy lines;
• Signed informed consent;
• Good understanding of the protocol and of the follow-up;
• Estimated life expectancy exceeding 3 months;
• At least one measurable metastatic lesion (RECIST criteria);
• Performance Status (WHO) of 0 to 2;
• Good haematological, hepatic and renal functions.

Inclusion criteria

for healthy subject

• Age ≥ 18 ans
• Signed informed consent;
• Good understanding of the protocol and of the follow-up;
• Good haematological, hepatic and renal functions.
• Test HIV and B and C hepatitis negative test
• No chronic or acute diseases

Exclusion criteria

for patients:

• Poor performance status (>2);
• Poor haematological, hepatic or renal functions;
• Uncontrolled chronic disease;
• Serious unhealed wound, ulcer or fracture within the previous month;
• Clinical or laboratory finding suggesting possible abnormalities in nucleosides urinary excretion;
• Pregnancy or breast-feeding during the previous month;
• Transmeridian trip of more than 4 time zones within the prior 2 weeks;
• Person with legal restriction to participate into clinical research, according to the current law in France.

Exclusion criteria

for healthy subject:

• Poor haematological, hepatic or renal functions;
• Uncontrolled chronic disease;
• Serious unhealed wound, ulcer or fracture within the previous month;
• Clinical or laboratory finding suggesting possible abnormalities in nucleosides urinary excretion;
• Pregnancy or breast-feeding during the previous month;
• Transmeridian trip of more than 4 time zones within the prior 2 weeks;
• Person with legal restriction to participate into clinical research, according to the current law in France.