Cancer Stem Cells in Acute Leukemia

Descriptive study of acute leukemia patients. Bone marrow aspirate or peripheral blood samples will be analyzed by next-generation sequencing for novel gene signatures and variations in transcriptional and epigenetic regulatory elements such as ARID5B and SALL4 variants.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Acute Leukemia

Age range

1 month–30 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sanford

Fargo, North Dakota, 58102, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Newly diagnosed or relapsed acute leukemia (AML or ALL)
Plan to undergo diagnostic bone marrow aspirate or peripheral blood if clinically indicated (i.e. WBC>50,000 and bone marrow contraindicated)
Age 1 month to 30 years
Understand and provide informed consent (subject if>18, legal guardian if<18)

Exclusion criteria

Age 0 to 4 weeks
Treatment related leukemia or leukemia secondary to MDS
Situations that would limit compliance with study requirements or ability to willingly give consent

Treatment and study plan

Bone marrow aspirate or peripheral blood sample collection

Diagnostic Test

Collection of specimen samples only

Primary outcomes

ARID5B polymorphism/mutation status

Time frame: 5 years

Correlation of our experimentally validated Arid5b dependent transcriptional signature with primary patient samples measured by patient ARID5B expression and polymorphisms.

Sponsors and collaborators

Lead sponsor

Sanford Health

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2028
Study completion: 2029
First posted: Nov 8, 2018
Registry last updated: Feb 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Active, Not Recruiting