Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention

Primary Objective:

Test the efficacy of RISE-YA to improve CRF

Secondary Objectives:

• Test the efficacy of RISE-YA to improve PA and physical function in fatigued YA brain tumor survivors.
• Determine A) cross-sectional associations of CRF with oxidative phosphorylation (OxPhos) and with inflammation, and B) the effect of RISE-YA on OxPhos and on inflammation.

Exploratory Objective:

Assess the effect of our supervised exercise intervention on patient-reported health-related quality of life, muscle mass development (BMI, skinfold and circumferences [waist, arm, and calf area]), patient-reported dietary intake, and exercise adherence and progression.

Inclusion criteria

• Is currently between the ages of 18-39 years
• Their primary brain tumor was diagnosed at age 15-39 years
• Is 6 months to <5 years post curative treatment
• Has been treated with chemotherapy and radiation, given most patients receive both therapies.
• Functional Assessment of Chronic Illness therapy (FACIT)-Fatigue ≤ 43. FACIT-Fatigue will be used as a screener because this 13-item scale can be completed relatively quickly in clinic
• Currently engage in <150 minutes of PA and < 2 sessions of muscle strengthening exercise per week (assessed by Godin Leisure-Time PA Questionnaire)
• Must be able to speak, write, and read English
• No exercise contraindication as assessed by screening with the Physical Activity Readiness Questionnaire PAR-Q+. In addition, participants' care teams will be notified of their participation in the study.
• Must be able to provide informed consent/assent.

Exclusion criteria

• Non-English speaking
• Screen failure for exercise safety
• Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
• Recent fracture or acute musculoskeletal injury that precludes ability to participate in supervised exercise training sessions
• History of underlying chronic disease, secondary malignances, germline genetic syndrome, or recurrent disease requiring re-irradiation of the brain
• Cognitive and/or major sensory deficits that would impede the completion of research activities and assessments as deemed by the clinical team.
• Self-report of pregnancy
• Prisoners
• Documented developmental disorders (e.g., Autism) or major psychotic illness (e.g., schizophrenia)