CAncer, NUtrition and Taste - Validation of the CANUT-QVA Questionnaire on Eating Habits in Cancer Patients

Cancer patients are at high risk of undernutrition, which is generally more pronounced for solid tumours (upper digestive tract, Ear Nose and Throat (ENT), bronchial tubes). This undernutrition leads to major weight loss and cachexia, and may represent the first sign of a call for a diagnosis of cancer. Cancer-related undernutrition is multi-factorial origins and has multiple consequences.

Chemotherapy treatments can induce various adverse effects in patients, including sensory disturbances at the beginning of treatment in addition to disturbances that may already be present before any treatment. The alteration of taste and odour, observed in 86% of patients, can induce a change in food preferences, promote the development of aversions, and therefore, lead to a significant reduction in the pleasure of eating. Loss of appetite, decreased food intake and the development of aversions to certain foods are situations experienced by a large proportion of patients treated with chemotherapy.

The assessment of taste disorders in patients treated with chemotherapy is established through the use of questionnaires, interviews and taste tests.

Changes in the perception and identification of salty, sweet, bitter and sour flavours are common in patients treated with chemotherapy.

As regards food products, patients report developing olfactory hypersensitivity mainly for food of animal origin, in particular for odours of fish, frying, cheese and eggs.

The CANUT project aims to study the effect of pathology and chemotherapy on gustatory and olfactory mechanisms, and in particular on interindividual differences in the perception and appreciation of food.

In order to monitor the evolution of patients' eating habits over time, the diet-related quality of life questionnaire (CANUT-QVA) was constructed from items selected from the Well-being related to Food questionnaire (WELLBFQ) after eliminating questions that were too general or expressed in terms of importance to use perception-related responses as a priority.

After this part, an evaluation of the 9 dimensions of the CANUT-QVA questionnaire will be performed.

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Key information

Conditions

Hematologic Cancer Chemotherapy Effect Chemotherapy-Induced Change Hematologic Diseases Hematologic Neoplasms Hemic and Lymphatic Diseases Malnutrition Neoplasms Neoplasms by Site Nervous System Diseases Neurologic Manifestations Nutrition Disorders Nutritional and Metabolic Diseases Olfactory Disorder Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Taste Disorders Undernutrition

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospices Civils de Lyon, Groupement Hospitalier Lyon Sud, Service pneumologie

Pierre-Bénite, 69310, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient with solid or hematological cancer (any stage of disease and any treatment) diagnosed within 12 months of inclusion.
Patient who does not object to participate in the trial
Patient affiliated to a social security system

Exclusion criteria

Minor patient (age <18 years).
Patient under trusteeship, curatorship or protective measures.
Patient who has already completed the questionnaire.
Patient not sufficiently able to speak French to answer the questionnaire

Treatment and study plan

Evaluation of the 9 dimensions of the CANUT-QVA questionnaire

Other

Evaluation of the contribution of a new questionnaire by patients with solid or hematological cancer according to 9 dimensions:

Making food
Place where the meals are eaten
Eating and drinking: Nutrition
Eating and drinking: The pleasure of tasting, chewing
Eating and drinking: Satiated, well being
Food preparation: Supply, choice, presentation
Eating and drinking: Feelings
After eating: heaviness, discomfort, hunger
Taste/Odour Problems to confirm the number and structure of factors obtained at the end of the pre-study and to remove redundant questions.

Primary outcomes

Validate the 9 dimensions of the CANUT-QVA questionnaire identified during the general population analysis.

Time frame: day 0

The main evaluation criterion will be the adequacy between the responses to the food quality of life questionnaire by patients and the structure of the 9 dimensions as presented in the context (relevance of the questions for each dimension).

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: CANUT-QVA

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2020
First posted: Jan 21, 2020
Registry last updated: Jul 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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