Adapted food intervention
Dietary SupplementAdapted food intervention
NCT Number: NCT04216641
Cancer promotes weight loss; it can also lead to particular complications for patients during treatment. A team led by Dr Michael Sawyer, showed the deleterious impact of undernutrition on the benefits of chemotherapy.
Cancer patients are at high risk of undernutrition, which is generally more pronounced for solid tumours (upper digestive tract, ENT, bronchial tubes…). This undernutrition leads to major weight loss and wasting, and may represent the first sign of a call for a diagnosis of cancer. Cancer-related undernutrition is multi-factorial in origin and has multiple consequences; it has its own prognostic value.
Chemotherapy treatments can induce various adverse effects in patients, including sensory disturbances at the beginning of treatment in addition to disturbances that may already be present before any treatment. Altered taste and odour, observed in 86% of patients, can induce a change in food preferences, promote the development of aversions, and therefore, lead to a significant reduction in the pleasure of eating. Loss of appetite, decreased food intake and the development of aversions to certain foods are situations experienced by a large proportion of patients undergoing chemotherapy.
The assessment of taste disorders in patients undergoing chemotherapy treatment is established through the use of questionnaires, interviews and taste tests.
Changes in the perception and identification of salty, sweet, bitter and sour flavours are common in patients undergoing chemotherapy.
The objective of CANUT is to study the effect of pathology and chemotherapy on gustatory and olfactory mechanisms and in particular on interindividual differences in the perception and appreciation of food.
In this study the investigators propose to adapt foods to best respond to sensory disorders related to the disease and/or treatment.
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Notify Me18 year and older
All sexes
Interventional
Not applicable
Hôpital Louis Pradel, Bron, France
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Adapted food intervention
Time frame: 12 weeks
The main endpoint of the CANUT-1 study is the proportion of cancer patients treated with chemotherapy (after 4 cycles) who will prefer at least an adapted version of a food compared to the standard version of the same food.
Time frame: Before Cycle 1(each cycle is 28 days) of chemotherapy treatment
Individual food assessment scores (standard food and adapted food to taste and smell disorders) before any treatment
Time frame: after 2 cycles (each cycle is 28 days) of chemotherapy
: Individual food assessment scores (standard food and adapted food to taste and smell disorders) after 2 cycles of chemotherapy
Time frame: after 4 cycles(each cycle is 28 days) of chemotherapy
: Individual food assessment scores (standard food and adapted food to taste and smell disorders) after 4 cycles of chemotherapy
Time frame: Before cycle 1(each cycle is 28 days) of chemotherapy treatment
The results of olfactory detection and identification, familiarity, pleasantness, intensity, edibility and trigeminal perception (fresh, hot, irritant, pungent) European Test of Olfactory Capabilities (ETOC) before any treatment, after 2 and 4 cycles of chemotherapy.
The results of olfactory detection and identification, familiarity, pleasantness, intensity, edibility and trigeminal perception (fresh, hot, irritant, pungent) European Test of Olfactory Capabilities (ETOC) before any treatment
Time frame: after 2 cycles (each cycle is 28 days) of chemotherapy
The results of olfactory detection and identification, familiarity, pleasantness, intensity, edibility and trigeminal perception (fresh, hot, irritant, pungent) European Test of Olfactory Capabilities (ETOC) after 2 of chemotherapy.
Time frame: after 4 cycles(each cycle is 28 days) of chemotherapy
The results of olfactory detection and identification, familiarity, pleasantness, intensity, edibility and trigeminal perception (fresh, hot, irritant, pungent) European Test of Olfactory Capabilities (ETOC) after and 4 cycles of chemotherapy.
Time frame: Before cycle 1(each cycle is 28 days) of treatment
The number of condiments added at the time of inclusion
Time frame: after 2 cycles(each cycle is 28 days) of chemotherapy
The number of condiments added after 2 cycles of chemotherapy.
Time frame: after 4 cycles(each cycle is 28 days) of chemotherapy
The number of condiments added after 4 cycles of chemotherapy.
Time frame: Before Cycle 1(each cycle is 28 days) of chemotherapy treatment
The proportion of patients who prefer to consume cold foods versus those who prefer to consume hot foods at the time of inclusion
Time frame: after 2 cycles(each cycle is 28 days) of chemotherapy
The proportion of patients who prefer to consume cold foods versus those who prefer to consume hot foods after 2 cycles of chemotherapy
Time frame: after 4 cycles(each cycle is 28 days) of chemotherapy
The proportion of patients who prefer to consume cold foods versus those who prefer to consume hot foods at 4 cycles of chemotherapy
Hospices Civils de Lyon
Other
Impact of a Food Improvement Strategy on Their Appreciation in a Population of Cancer Patients Treated With Chemotherapy
Acronym: CANUT-1
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